Expression pattern of hypoxia-related genes in odontogenic cysts

The aim of the present study was to reveal the effects of hypoxia-associated signaling in odontogenic cysts. The expression levels of genes involved in the hypoxia-associated signaling pathway were determined by quantitative Polymerase Chain Reaction (PCR) method. As a result, it was found that phos...

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Bibliographic Details
Published in:Archives of oral biology 2023-04, Vol.148, p.105639-105639, Article 105639
Main Authors: Ege, Bilal, Bozgeyik, Esra, Bayazıt, Seyma, Bozgeyik, Ibrahim, Erdogmus, Zozan, Koparal, Mahmut
Format: Article
Language:English
Subjects:
Dentigerous Cyst
HIF1A
Humans
Hypoxia
Odontogenic Cysts - genetics
Odontogenic keratocyst
Phosphatidylinositol 3-Kinases
Radicular cyst
Radicular Cyst - metabolism
Radicular Cyst - pathology
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Summary:The aim of the present study was to reveal the effects of hypoxia-associated signaling in odontogenic cysts. The expression levels of genes involved in the hypoxia-associated signaling pathway were determined by quantitative Polymerase Chain Reaction (PCR) method. As a result, it was found that phosphatase and tensin homolog (PTEN) expression was low (p = 0.037), and the expression levels of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) (p = 0.0127), hypoxia inducible factor 1 alpha (HIF1A) (p 
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2023.105639