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Relapsed Synovial Sarcoma: Treatment Options
Opinion statement Synovial sarcoma (SS) is a fusion-driven subtype of sarcoma that is a more chemo-sensitive subtype of soft tissue sarcoma. While chemotherapy options are currently standard of care, our fundamental understanding of the biology of SS is driving new therapies. We will review the curr...
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Published in: | Current treatment options in oncology 2023-03, Vol.24 (3), p.229-239 |
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container_title | Current treatment options in oncology |
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creator | Weiss, Mia C. Van Tine, Brian A. |
description | Opinion statement
Synovial sarcoma (SS) is a fusion-driven subtype of sarcoma that is a more chemo-sensitive subtype of soft tissue sarcoma. While chemotherapy options are currently standard of care, our fundamental understanding of the biology of SS is driving new therapies. We will review the current standard of care, as well as the current therapies showing promise in a clinical trial. It is our hope that by encouraging participation in clinical trials, the fundamental therapies available for SS will change the current treatment paradigm. |
doi_str_mv | 10.1007/s11864-023-01056-5 |
format | article |
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Synovial sarcoma (SS) is a fusion-driven subtype of sarcoma that is a more chemo-sensitive subtype of soft tissue sarcoma. While chemotherapy options are currently standard of care, our fundamental understanding of the biology of SS is driving new therapies. We will review the current standard of care, as well as the current therapies showing promise in a clinical trial. It is our hope that by encouraging participation in clinical trials, the fundamental therapies available for SS will change the current treatment paradigm.</description><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Sarcoma</subject><subject>Sarcoma (SH Okuno</subject><subject>Sarcoma, Synovial - diagnosis</subject><subject>Sarcoma, Synovial - therapy</subject><subject>Section Editor</subject><subject>Soft Tissue Neoplasms</subject><subject>Soft tissue sarcoma</subject><subject>Synovial sarcoma</subject><subject>Topical Collection on Sarcoma</subject><issn>1527-2729</issn><issn>1534-6277</issn><issn>1534-5277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAQx4Mo7vr4Ah6k4MWD0cmjSepNFl-wsOCu55BNU-nSl0kr7Le3tauCB08zML_5z_BD6IzANQGQN4EQJTgGyjAQiAWO99CUxIxjQaXcH3oqMZU0maCjEDYANOaQHKIJE0pIppIpunpxhWmCS6Pltqo_clNES-NtXZrbaOWdaUtXtdGiafO6CifoIDNFcKe7eoxeH-5Xsyc8Xzw-z-7m2DIZt9iATImggiWCpyo2ljAwKec0ziBLFWOGK0LjdJ1YZYUwlDunQGWOgyJWWHaMLsfcxtfvnQutLvNgXVGYytVd0FQqxhMpuOjRiz_opu581X83UJwD6830FB0p6-sQvMt04_PS-K0moAeXenSpe5f6y6Uels530d26dOnPyre8HmAjEPpR9eb87-1_Yj8BWQV8cg</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Weiss, Mia C.</creator><creator>Van Tine, Brian A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8457-0523</orcidid></search><sort><creationdate>20230301</creationdate><title>Relapsed Synovial Sarcoma: Treatment Options</title><author>Weiss, Mia C. ; Van Tine, Brian A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a07d16263964d85ac130ad4425f0fd833a48125db9c8c66a24ee808fe4081c6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Sarcoma</topic><topic>Sarcoma (SH Okuno</topic><topic>Sarcoma, Synovial - diagnosis</topic><topic>Sarcoma, Synovial - therapy</topic><topic>Section Editor</topic><topic>Soft Tissue Neoplasms</topic><topic>Soft tissue sarcoma</topic><topic>Synovial sarcoma</topic><topic>Topical Collection on Sarcoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiss, Mia C.</creatorcontrib><creatorcontrib>Van Tine, Brian A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Current treatment options in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, Mia C.</au><au>Van Tine, Brian A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relapsed Synovial Sarcoma: Treatment Options</atitle><jtitle>Current treatment options in oncology</jtitle><stitle>Curr. Treat. Options in Oncol</stitle><addtitle>Curr Treat Options Oncol</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>24</volume><issue>3</issue><spage>229</spage><epage>239</epage><pages>229-239</pages><issn>1527-2729</issn><eissn>1534-6277</eissn><eissn>1534-5277</eissn><abstract>Opinion statement
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subjects | Chemotherapy Clinical trials Humans Medicine Medicine & Public Health Oncology Sarcoma Sarcoma (SH Okuno Sarcoma, Synovial - diagnosis Sarcoma, Synovial - therapy Section Editor Soft Tissue Neoplasms Soft tissue sarcoma Synovial sarcoma Topical Collection on Sarcoma |
title | Relapsed Synovial Sarcoma: Treatment Options |
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