Combining semi-quantitative rating and automated brain volumetry in MRI evaluation of patients with probable behavioural variant of fronto-temporal dementia: an added value for clinical practise?

Purpose To evaluate the diagnostic value of combined semiquantitative and quantitative assessment of brain atrophy in the diagnostic workup of the behavioural-variant of frontotemporal dementia (bvFTD). Methods Three neuroradiologists defined brain atrophy grading and identified atrophy pattern sugg...

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Published in:Neuroradiology 2023-06, Vol.65 (6), p.1025-1035
Main Authors: Calloni, Sonia Francesca, Vezzulli, Paolo Quintiliano, Castellano, Antonella, Leone, Riccardo, Basaia, Silvia, von Loon, Almar, Spinelli, Edoardo Gioele, Magnani, Giuseppe, Caso, Francesca, Agosta, Federica, Filippi, Massimo, Falini, Andrea
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Language:English
Subjects:
Atrophy
Atrophy - pathology
Automation
Brain
Brain - diagnostic imaging
Brain - pathology
Dementia
Dementia disorders
Diagnostic Neuroradiology
Evaluation
Frontotemporal dementia
Frontotemporal Dementia - diagnostic imaging
Frontotemporal Dementia - pathology
Humans
Imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Neuroimaging
Neurology
Neuropsychological Tests
Neuroradiology
Neurosciences
Neurosurgery
Observers
Radiology
Software
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container_title Neuroradiology
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creator Calloni, Sonia Francesca
Vezzulli, Paolo Quintiliano
Castellano, Antonella
Leone, Riccardo
Basaia, Silvia
von Loon, Almar
Spinelli, Edoardo Gioele
Magnani, Giuseppe
Caso, Francesca
Agosta, Federica
Filippi, Massimo
Falini, Andrea
description Purpose To evaluate the diagnostic value of combined semiquantitative and quantitative assessment of brain atrophy in the diagnostic workup of the behavioural-variant of frontotemporal dementia (bvFTD). Methods Three neuroradiologists defined brain atrophy grading and identified atrophy pattern suggestive of bvFTD on 3D-T1 brain MRI of 112 subjects using a semiquantitative rating scale (Kipps’). A quantitative atrophy assessment was performed using two different automated software (Quantib® ND and Icometrix®). A combined semiquantitative and quantitative assessment of brain atrophy was made to evaluate the improvement in brain atrophy grading to identify probable bvFTD patients. Results Observers’ performances in the diagnosis of bvFTD were very good for Observer 1 ( k value = 0.881) and 2 ( k value = 0.867), substantial for Observer 3 ( k value = 0.741). Semiquantitative atrophy grading of all the observers showed a moderate and a poor correlation with the volume values calculated by Icometrix® and by Quantib® ND, respectively. For the definition of neuroradiological signs presumptive of bvFTD, the use of Icometrix® software improved the diagnostic accuracy for Observer 1 resulting in an AUC of 0.974, and for Observer 3 resulting in a AUC of 0.971 ( p -value 
doi_str_mv 10.1007/s00234-023-03133-w
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Methods Three neuroradiologists defined brain atrophy grading and identified atrophy pattern suggestive of bvFTD on 3D-T1 brain MRI of 112 subjects using a semiquantitative rating scale (Kipps’). A quantitative atrophy assessment was performed using two different automated software (Quantib® ND and Icometrix®). A combined semiquantitative and quantitative assessment of brain atrophy was made to evaluate the improvement in brain atrophy grading to identify probable bvFTD patients. Results Observers’ performances in the diagnosis of bvFTD were very good for Observer 1 ( k value = 0.881) and 2 ( k value = 0.867), substantial for Observer 3 ( k value = 0.741). Semiquantitative atrophy grading of all the observers showed a moderate and a poor correlation with the volume values calculated by Icometrix® and by Quantib® ND, respectively. For the definition of neuroradiological signs presumptive of bvFTD, the use of Icometrix® software improved the diagnostic accuracy for Observer 1 resulting in an AUC of 0.974, and for Observer 3 resulting in a AUC of 0.971 ( p -value &lt; 0.001). The use of Quantib® ND software improved the diagnostic accuracy for Observer 1 resulting in an AUC of 0.974, and for Observer 3 resulting in a AUC of 0.977 ( p -value &lt; 0.001). No improvement was observed for Observer 2. Conclusion Combining semiquantitative and quantitative brain imaging evaluation allows to reduce discrepancies in the neuroradiological diagnostic workup of bvFTD by different readers.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-023-03133-w</identifier><identifier>PMID: 36867204</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atrophy ; Atrophy - pathology ; Automation ; Brain ; Brain - diagnostic imaging ; Brain - pathology ; Dementia ; Dementia disorders ; Diagnostic Neuroradiology ; Evaluation ; Frontotemporal dementia ; Frontotemporal Dementia - diagnostic imaging ; Frontotemporal Dementia - pathology ; Humans ; Imaging ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine &amp; Public Health ; Neuroimaging ; Neurology ; Neuropsychological Tests ; Neuroradiology ; Neurosciences ; Neurosurgery ; Observers ; Radiology ; Software</subject><ispartof>Neuroradiology, 2023-06, Vol.65 (6), p.1025-1035</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-73760e3510f0695dd83a5c7dd01c12aa6687baa3817406628965221867f0d8733</cites><orcidid>0000-0002-6899-422X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36867204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calloni, Sonia Francesca</creatorcontrib><creatorcontrib>Vezzulli, Paolo Quintiliano</creatorcontrib><creatorcontrib>Castellano, Antonella</creatorcontrib><creatorcontrib>Leone, Riccardo</creatorcontrib><creatorcontrib>Basaia, Silvia</creatorcontrib><creatorcontrib>von Loon, Almar</creatorcontrib><creatorcontrib>Spinelli, Edoardo Gioele</creatorcontrib><creatorcontrib>Magnani, Giuseppe</creatorcontrib><creatorcontrib>Caso, Francesca</creatorcontrib><creatorcontrib>Agosta, Federica</creatorcontrib><creatorcontrib>Filippi, Massimo</creatorcontrib><creatorcontrib>Falini, Andrea</creatorcontrib><title>Combining semi-quantitative rating and automated brain volumetry in MRI evaluation of patients with probable behavioural variant of fronto-temporal dementia: an added value for clinical practise?</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><addtitle>Neuroradiology</addtitle><description>Purpose To evaluate the diagnostic value of combined semiquantitative and quantitative assessment of brain atrophy in the diagnostic workup of the behavioural-variant of frontotemporal dementia (bvFTD). Methods Three neuroradiologists defined brain atrophy grading and identified atrophy pattern suggestive of bvFTD on 3D-T1 brain MRI of 112 subjects using a semiquantitative rating scale (Kipps’). A quantitative atrophy assessment was performed using two different automated software (Quantib® ND and Icometrix®). A combined semiquantitative and quantitative assessment of brain atrophy was made to evaluate the improvement in brain atrophy grading to identify probable bvFTD patients. Results Observers’ performances in the diagnosis of bvFTD were very good for Observer 1 ( k value = 0.881) and 2 ( k value = 0.867), substantial for Observer 3 ( k value = 0.741). Semiquantitative atrophy grading of all the observers showed a moderate and a poor correlation with the volume values calculated by Icometrix® and by Quantib® ND, respectively. For the definition of neuroradiological signs presumptive of bvFTD, the use of Icometrix® software improved the diagnostic accuracy for Observer 1 resulting in an AUC of 0.974, and for Observer 3 resulting in a AUC of 0.971 ( p -value &lt; 0.001). The use of Quantib® ND software improved the diagnostic accuracy for Observer 1 resulting in an AUC of 0.974, and for Observer 3 resulting in a AUC of 0.977 ( p -value &lt; 0.001). No improvement was observed for Observer 2. 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Methods Three neuroradiologists defined brain atrophy grading and identified atrophy pattern suggestive of bvFTD on 3D-T1 brain MRI of 112 subjects using a semiquantitative rating scale (Kipps’). A quantitative atrophy assessment was performed using two different automated software (Quantib® ND and Icometrix®). A combined semiquantitative and quantitative assessment of brain atrophy was made to evaluate the improvement in brain atrophy grading to identify probable bvFTD patients. Results Observers’ performances in the diagnosis of bvFTD were very good for Observer 1 ( k value = 0.881) and 2 ( k value = 0.867), substantial for Observer 3 ( k value = 0.741). Semiquantitative atrophy grading of all the observers showed a moderate and a poor correlation with the volume values calculated by Icometrix® and by Quantib® ND, respectively. 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subjects Atrophy
Atrophy - pathology
Automation
Brain
Brain - diagnostic imaging
Brain - pathology
Dementia
Dementia disorders
Diagnostic Neuroradiology
Evaluation
Frontotemporal dementia
Frontotemporal Dementia - diagnostic imaging
Frontotemporal Dementia - pathology
Humans
Imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Neuroimaging
Neurology
Neuropsychological Tests
Neuroradiology
Neurosciences
Neurosurgery
Observers
Radiology
Software
title Combining semi-quantitative rating and automated brain volumetry in MRI evaluation of patients with probable behavioural variant of fronto-temporal dementia: an added value for clinical practise?
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