Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source

Folate intake and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene may affect folate metabolism in infants. We investigated the association between infant’s MTHFR C677T genotype, the dietary folate source, and concentrations of folate markers in the blood. We studied 110 breastf...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2023-03, Vol.117 (3), p.509-517
Main Authors: Obeid, Rima, Warnke, Ines, Wittke, Anja, Bendik, Igor, Troesch, Barbara, Schoop, Rotraut, Hecht, Christina, Demmelmair, Johann, Koletzko, Berthold
Format: Article
Language:English
Subjects:
(6S)-5-methyltetrahydrofolate
5,10-methylenetetrahydrofolate reductase
Babies
Baby foods
Blood
Breast Feeding
breastfeeding
Breastfeeding & lactation
Catabolites
Clinical Relevance
Diet
Dietary intake
Erythrocytes
Female
folate catabolism
folate requirements
Folic Acid
formula feeding
Genotype
Genotype & phenotype
Humans
Infant
Infant formulas
infant nutrition
Infants
Legislation
Metabolism
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2)
Plasma
Reductases
Vitamin B
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Summary:Folate intake and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene may affect folate metabolism in infants. We investigated the association between infant’s MTHFR C677T genotype, the dietary folate source, and concentrations of folate markers in the blood. We studied 110 breastfed infants (reference) and 182 infants who were randomly assigned to receive infant formulas enriched with either 78 μg folic acid or 81 μg (6S)-5-methyltetrahydrofolate (5-MTHF) per 100 g milk powder for 12 wk. The blood samples were available at the ages of
ISSN:0002-9165
1938-3207
DOI:10.1016/j.ajcnut.2022.09.002