Iodine-Catalyzed Borylation of Benzylic Alcohols

Direct borylation of benzylic alcohols has been achieved via an iodine-catalyzed process. This transition-metal-free borylation transformation is compatible with various functional groups and provides a practical and convenient method to access important and useful benzylic boronate esters from wide...

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Bibliographic Details
Published in:Organic letters 2023-03, Vol.25 (10), p.1701-1705
Main Authors: Yin, Chunyu, Luo, Lu, Zhang, Hua
Format: Article
Language:English
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Summary:Direct borylation of benzylic alcohols has been achieved via an iodine-catalyzed process. This transition-metal-free borylation transformation is compatible with various functional groups and provides a practical and convenient method to access important and useful benzylic boronate esters from widely available benzylic alcohols. Preliminary mechanistic investigations indicated that benzylic iodide and radicals are involved as the key intermediates in this borylation reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00367