Evaluation of T helper17 as skeletal homeostasis factor in peripheral blood mononuclear cells and T helper cells of end-stage renal disease cases with impaired parathyroid hormone

• Published in: Molecular biology reports 2023-05, Vol.50 (5), p.4097-4104
• Main Authors: Motavalli, Roza, Soltani-Zangbar, Mohammad Sadegh, fereydoonzadeh, Khadijeh, Hajivalili, Mahsa, Ahmadian Heris, Javad, Kahroba, Houman, Niknafs, Bahram, Motavalli Khiavi, Farhad, Dolati, Sanam, Sadeghi, Mohammadreza, Yousefi, Mehdi, Etemadi, Jalal
• Format: Article
• Language: English
• Subjects: Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; CD4 antigen; Cell differentiation; Cytokines; Cytokines - metabolism; End-stage renal disease; Flow cytometry; Gene expression; Helper cells; Hemodialysis; Histology; Homeostasis; Humans; Immune system; Interleukin 17; Interleukin 23; Kidney diseases; Kidney Failure, Chronic; Leukocytes, Mononuclear; Life Sciences; Lymphocytes T; Morphology; Original Article; Parathyroid hormone; Parathyroid Hormone - metabolism; Peripheral blood mononuclear cells; Renal Dialysis; Renal failure; Stat3 protein; Th17 Cells - metabolism; Transcription factors
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-023-08306-7

Background Chronic renal failure is mainly connected with high and low parathyroid hormone (PTH) levels and immunological impairments. The present study aimed to evaluate T helper 17 (Th17) cells as a crucial modulator of the immune system and skeletal homeostasis in hemodialysis patients with impaired intact PTH (iPTH). Methods In this research, blood samples were taken from ESRD patients with high (> 300 pg/mL), normal (150–300 pg/mL), and low (