A Comprehensive Overview of Sensors Applications for the Diagnosis of SARS-CoV-2 and of Drugs Used in its Treatment

During the COVID-19 process, determination-based analytical chemistry studies have had a major place at every stage. Many analytical techniques have been used in both diagnostic studies and drug analysis. Among these, electrochemical sensors are frequently preferred due to their high sensitivity, se...

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Bibliographic Details
Published in:Critical reviews in analytical chemistry 2024-10, Vol.54 (7), p.2517-2537
Main Authors: Cetinkaya, Ahmet, Kaya, S. Irem, Ozkan, Sibel A.
Format: Article
Language:English
Subjects:
Analytical chemistry
Biological properties
Biological samples
biomarker
biosensor
Biosensors
Chemical sensors
COVID-19
determination
Diagnosis
Drug development
Drug solvents
Drugs
electrochemical sensor
Electrochemistry
Medical research
Organic solvents
Ribavirin
Sample preparation
SARS-CoV-2
Sensors
Severe acute respiratory syndrome coronavirus 2
Viral diseases
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Summary:During the COVID-19 process, determination-based analytical chemistry studies have had a major place at every stage. Many analytical techniques have been used in both diagnostic studies and drug analysis. Among these, electrochemical sensors are frequently preferred due to their high sensitivity, selectivity, short analysis time, reliability, ease of sample preparation, and low use of organic solvents. For the determination of drugs used in the SARS-CoV-2, such as favipiravir, molnupiravir, ribavirin, etc., electrochemical (nano)sensors are widely used in both pharmaceutical and biological samples. Diagnosis is the most critical step in the management of the disease, and electrochemical sensor tools are widely preferred for this purpose. Diagnostic electrochemical sensor tools can be biosensor-, nano biosensor-, or MIP-based sensors and utilize a wide variety of analytes such as viral proteins, viral RNA, antibodies, etc. This review overviews the sensor applications in SARS-CoV-2 in terms of diagnosis and determination of drugs by evaluating the most recent studies in the literature. In this way, it is aimed to compile the developments so far by shedding light on the most recent studies and giving ideas to researchers for future studies.
ISSN:1040-8347
1547-6510
1547-6510
DOI:10.1080/10408347.2023.2186693