Total recall? Understanding the effect of antigenic distance on original antigenic sin

Vaccination‐induced antibodies are critical for protective immunity against pathogenic threats. “Original antigenic sin” (OAS), also referred to as imprinting, is the observed phenomenon whereby exposure to antigenic stimuli bias future antibody responses. This Commentary describes a recently elegan...

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Bibliographic Details
Published in:Immunology and cell biology 2023-05, Vol.101 (5), p.377-380
Main Authors: Burnett, Deborah L, Bull, Rowena A
Format: Article
Language:English
Subjects:
antibodies
Antibodies, Viral
Antibody Formation
Antigens
Immune imprinting
imprinting
Vaccination
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Summary:Vaccination‐induced antibodies are critical for protective immunity against pathogenic threats. “Original antigenic sin” (OAS), also referred to as imprinting, is the observed phenomenon whereby exposure to antigenic stimuli bias future antibody responses. This Commentary describes a recently elegant model published in Nature by Schiepers et al. which allows us to delve deeper into the processes and mechanisms of OAS than ever before.
ISSN:0818-9641
1440-1711
DOI:10.1111/imcb.12638