Association between relative peripheral refraction and corresponding electro‐retinal signals

• Published in: Ophthalmic & physiological optics 2023-05, Vol.43 (3), p.482-493
• Main Authors: Gupta, Satish Kumar, Chakraborty, Ranjay, Verkicharla, Pavan Kumar
• Format: Article
• Language: English
• Subjects: Electrophysiology; Electroretinography; electro‐retinal signals; Eye; Fovea Centralis; Horizontal cells; Humans; Hyperopia; multifocal electroretinogram; Myopia; Myopia - diagnosis; peripheral refraction; Refraction; Refraction, Ocular; Retina; Retina - physiology; retinal defocus; Young Adult; Young adults
• ISSN: 0275-5408; 1475-1313
• DOI: 10.1111/opo.13114

Purpose Considering the potential role of the peripheral retina in refractive development and given that peripheral refraction varies significantly with increasing eccentricity from the fovea, we investigated the association between relative peripheral refraction (RPR) and corresponding relative peripheral multifocal electroretinogram (mfERG) responses (electro‐retinal signals) from the central to the peripheral retina in young adults. Methods Central and peripheral refraction using an open‐field autorefractor and mfERG responses using an electrophysiology stimulator were recorded from the right eyes of 17 non‐myopes and 24 myopes aged 20–27 years. The relative mfERG N1, P1 and N2 components (amplitude density and implicit time) of a mfERG waveform were compared with the corresponding RPR measurements at the best‐matched eccentricities along the principal meridians, that is at the fovea (0°), horizontal (±5°, ±10° and ± 25°) and vertical meridians (±10° and ± 15°). Results The mean absolute mfERG N1, P1 and N2 amplitude densities (nV/deg2) were maximum at the fovea in both non‐myopes (N1: 57.29 ± 14.70 nV/deg2, P1: 106.29 ± 24.46 nV/deg2, N2: 116.41 ± 27.96 nV/deg2) and myopes (N1: 56.25 ± 15.79 nV/deg2, P1: 100.79 ± 30.81 nV/deg2, N2: 105.75 ± 37.91 nV/deg2), which significantly reduced with increasing retinal eccentricity (p