Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade‐assessed systematic review and dose–response meta‐analysis of randomized controlled trials

• Published in: Phytotherapy research 2023-04, Vol.37 (4), p.1703-1728
• Main Authors: Dehzad, Mohammad Jafar, Ghalandari, Hamid, Nouri, Mehran, Askarpour, Moein
• Format: Article
• Language: English
• Subjects: Adipokines; Adiponectin; Adiponectin - therapeutic use; Adipose tissue; Adult; Anthropometry; Body fat; Body mass; Body mass index; Body size; Body weight; Clinical trials; Curcuma; Curcumin; Curcumin - therapeutic use; Dietary Supplements - analysis; Heterogeneity; Humans; Leptin; Leptin - therapeutic use; Meta-analysis; Obesity; Obesity - drug therapy; Quality assessment; Quality control; Randomized Controlled Trials as Topic; RCTs; Search engines; Supplements; turmeric; Weight reduction
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.7800

In the present study, we explored the effect of curcumin/turmeric supplementation on anthropometric indices of obesity, leptin, and adiponectin. We searched PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar up to August 2022. Randomized clinical trials (RCTs) investigating the impact of curcumin/turmeric on obesity indices and adipokines were included. We applied the Cochrane quality assessment tool to evaluate the risk of bias. The registration number is CRD42022350946. Sixty eligible RCTs, with a total sample size of 3691 individuals were included for quantitative analysis. We found that supplementation with curcumin/turmeric significantly reduced body weight (WMD: −0.82 kg, 95% CI: −1.30, −0.35; p = 0.001), body mass index (WMD: −0.30 kg/m2, 95% CI: −0.53, −0.06, p = 0.013), waist circumference (WMD: −1.31 cm, 95% CI: −1.94, −0.69, p