Photosensitized Vicinal Sulfonylamination of Alkenes with Oxime Ester and DABCO·(SO2)2

A metal-free photosensitized three-component reaction of oxime esters, alkenes, and DABCO·(SO2)2 was developed. This protocol could accommodate a wide substrate scope, including activated and unactivated alkenes and aryl and aliphatic carboxylic acid oxime esters, delivering a broad range of β-amino...

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Bibliographic Details
Published in:Organic letters 2023-03, Vol.25 (10), p.1782-1786
Main Authors: Yuan, Chu-Ping, Zheng, Yu, Xie, Zhen-Zhen, Deng, Ke-Yi, Chen, Hong-Bin, Xiang, Hao-Yue, Chen, Kai, Yang, Hua
Format: Article
Language:English
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Summary:A metal-free photosensitized three-component reaction of oxime esters, alkenes, and DABCO·(SO2)2 was developed. This protocol could accommodate a wide substrate scope, including activated and unactivated alkenes and aryl and aliphatic carboxylic acid oxime esters, delivering a broad range of β-amino sulfones in moderate to high yields. The insertion of SO2 as a linker moiety allows the manipulation of the functionality in the reaction process, expanding the utility of oxime esters as bifunctional reagents.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00559