Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis

Strongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of Strongyloides stercoralis infection in alcoholic patients, the levels of circulating cytokines...

Full description

Saved in:
Bibliographic Details
Published in:Parasite immunology 2023-05, Vol.45 (5), p.e12977-n/a
Main Authors: Souza, Alex Bruno da Silva, De Souza, Joelma Nascimento, Oliveira, Cíntia de Lima, Barreto, Nilo Manoel Pereira Vieira, Costa, Wéslei Almeida, Oliveira, Ricardo Riccio, Teixeira, Márcia Cristina Aquino, Soares, Neci Matos
Format: Article
Language:English
Subjects:
Alcoholics
Alcoholism
Alcoholism - complications
Alcoholism - parasitology
Animals
cytokin
Cytokines
Equidae
Feces
Humans
Immune response
Interleukin 15
Interleukin-4
Larvae
Lymphocytes T
Serum levels
Strongyloides stercoralis
Strongyloidiasis
Strongyloidiasis - parasitology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Strongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of Strongyloides stercoralis infection in alcoholic patients, the levels of circulating cytokines (IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, IL‐15 and IL‐17), and its correlation with modulation of parasitic load in alcoholic individuals infected with S. stercoralis. A total of 336 alcoholic patients, treated at the Alcoholic Care and Treatment Center were included in this study. The cytokine levels were measured by a commercial ELISA in 80 sera divided into four groups with 20 individuals each: alcoholics infected (ASs+) and not infected (ASs‐) with S. stercoralis and non‐alcoholics infected (NASs+) and not infected (NASs‐) with the helminth. S. stercoralis frequency in alcoholic patients was 16.1% (54/336). The parasitic load varied from 1 to 546 larvae/g of faeces, median and interquartile range (IQR) of 9 and 1.0–62.5 larvae/g of faeces, while in non‐alcoholic individuals the parasitic load was less than 10 larvae/g of faeces. Levels of circulating IL‐4 were significantly higher in ASs+ when compared with NASs‐ group (p 
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12977