A mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals

Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown. To assess the effect...

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Bibliographic Details
Published in:Journal of oral microbiology 2023-12, Vol.15 (1), p.2185962-2185962
Main Authors: Pascual, Javier, Mira Otal, Javier, Torrent-Silla, Daniel, Porcar, Manuel, Vilanova, Cristina, Vivancos Cuadras, Fernando
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Blood pressure
Chloride
cymen-5-ol
Microbiomes
Mode of action
Mouthwash
Mouthwashes
oral microbiome
Original
Pathogens
Relative abundance
Zinc
Zinc chloride
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Summary:Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown. To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals. A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach. Analysis of the oral microbiome showed that the mouthwash selectively targeted potential oral pathogens while maintaining the integrity of the rest of the microbiome. Specifically, the relative abundance of several potentially pathogenic bacterial taxa, namely Fusobacteriota, Prevotella, Actinomyces, Granulicatella, Abiotrophia, Lautropia, Lachnoanaerobaculum, Eubacterium (nodatum group) and Absconditabacteriales (SR1) decreased, while the growth of Rothia, a nitrate-reducing bacterium beneficial for blood pressure, was stimulated. The use of o-cymen-5-ol and zinc chloride as antimicrobial agents in oral mouthwashes is a valuable alternative to classical antimicrobial agents.
ISSN:2000-2297
2000-2297
DOI:10.1080/20002297.2023.2185962