Efficacy of autologous platelet-rich plasma for long-term glucocorticoids caused chronic wound: a case report

The repair of bone explore wounds is one of the difficult problems in plastic and reconstruction surgery. Platelet-rich plasma (PRP) is a safe and efficient therapeutic option for various trauma, including Osteoarticular, musculoskeletal, and Wound injuries. However, the preparation and storage of P...

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Bibliographic Details
Published in:Cell and tissue banking 2023-12, Vol.24 (4), p.705-710
Main Authors: Zhang, Ziang, Long, Jie, Geng, Jian, Xia, Wensen
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Blood
Blood platelets
Bone healing
Case reports
Cell Biology
Fistula
Glucocorticoids
Growth factors
Hospitals
Life Sciences
Plasma
Plastic surgery
Platelets
Reconstructive surgery
Rheumatoid arthritis
Suctioning
Tissue engineering
Transplant Surgery
Trauma
Wound healing
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Summary:The repair of bone explore wounds is one of the difficult problems in plastic and reconstruction surgery. Platelet-rich plasma (PRP) is a safe and efficient therapeutic option for various trauma, including Osteoarticular, musculoskeletal, and Wound injuries. However, the preparation and storage of PRP becomes challenging for patients with poor systemic status and requiring multi-use of PRP. The availability of safe, reliable tissue bank makes it possible. We report a case of a 42-year-old woman patient with a chronic hip wound combined with ischium bone exploration. And the patient who was treated with long-term glucocorticoids for rheumatoid arthritis has been through the experience of extensive conservative management. Thereafter necrosectomy and Vacuum-Assisted Closure (VAC) surgical procedure failed, and a PRP daily injection was performed at the ischial muscle and soft tissue. Neo-muscle appeared around the explored ischium bone after 8 weeks of injection and Complete wound healing was obtained in 3 months.
ISSN:1389-9333
1573-6814
DOI:10.1007/s10561-023-10083-3