In vitro toxicity of naringin and berberine alone, and encapsulated within PMMA nanoparticles

Phytochemical compounds, such as naringin and berberine, have been used for many years due to their antioxidant activities, and consequently, beneficial health effects. In this study, it was aimed to evaluate the antioxidant properties of naringin, berberine and poly(methylmethacrylate) (PMMA) nanop...

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Bibliographic Details
Published in:Toxicology in vitro 2023-06, Vol.89, p.105580-105580, Article 105580
Main Authors: Secerli, Jülide, Adatepe, Şeyma, Altuntas, Sevde, Topal, Gizem Rüya, Erdem, Onur, Bacanlı, Merve
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Antioxidant
Antioxidants - chemistry
Apoptosis
Berberine - chemistry
Berberine - toxicity
Caco-2 Cells
Cytotoxicity
Genotoxicity
Humans
Mice
MTT
Nanoparticles - toxicity
Polymethyl Methacrylate - toxicity
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Summary:Phytochemical compounds, such as naringin and berberine, have been used for many years due to their antioxidant activities, and consequently, beneficial health effects. In this study, it was aimed to evaluate the antioxidant properties of naringin, berberine and poly(methylmethacrylate) (PMMA) nanoparticles (NPs) encapsulated with naringin or berberine and their possible cytotoxic, genotoxic, and apoptotic effects on mouse fibroblast (NIH/3 T3) and colon cancer (Caco-2) cells. According to the results of the study, it was found that the 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition antioxidant activity of naringin, berberine, and naringin or berberine encapsulated PMMA NPs, was significantly increased at higher tested concentrations due to the antioxidant effects of naringin, berberine and naringin or berberine encapsulated PMMA NPs. As a result of the cytotoxicity assay, after 24-, 48- and 72-h of exposure, all of the studied compounds caused cytotoxic effects in both cell lines. Genotoxic effects of studied compounds were not registered at lower tested concentrations. Based on these data, polymeric nanoparticles encapsulated with naringin or berberine may contribute to new treatment approaches for cancer, but further in vivo and in vitro research is required. [Display omitted] •PMMA NPs are biocompatible.•Naringin and berberine encapsulated PMMA NPs have promising effects for cancer treatment.
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2023.105580