The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of the first known miRNAs in mammals is miR-21....

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Bibliographic Details
Published in:Stem cell reviews and reports 2023-07, Vol.19 (5), p.1232-1251
Main Authors: Kalhori, Mohammad Reza, Soleimani, Masoud, Alibakhshi, Reza, Kalhori, Amir Ali, Mohamadi, Parisa, Azreh, Rasoul, Farzaei, Mohammad Hosien
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Cell Biology
Cell differentiation
Cell proliferation
Cell self-renewal
Life Sciences
MicroRNAs
miRNA
Non-coding RNA
Pluripotency
Regenerative medicine
Regenerative Medicine/Tissue Engineering
Spinal cord
Stem Cells
Tissue engineering
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Summary:MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of the first known miRNAs in mammals is miR-21. Cancer-related studies have shown that this miRNA has proto-oncogene activity and is elevated in cancers. However, it is confirmed that miR-21 inhibits stem cell pluripotency and self-renewal and induces differentiation by targeting various genes. Regenerative medicine is a field of medical science that tries to regenerate and repair damaged tissues. Various studies have shown that miR-21 plays an essential role in regenerative medicine by affecting stem cell proliferation and differentiation. In this review, we will discuss the function of miR-21 in regenerative medicine of the liver, nerve, spinal cord, wound, bone, and dental tissues. In addition, the function of natural compounds and lncRNAs will be analyzed as potential regulators of miR-21 expression in regenerative medicine. Graphical Abstract
ISSN:2629-3269
2629-3277
DOI:10.1007/s12015-023-10510-8