Associations of pre- and postnatal exposures with optic nerve status in young adults

We aimed to explore the effect of multiple pre- and postnatal exposures on optic nerve status in young adults due to this critical period for development. We analysed peripapillary retinal nerve fibre layer (RNFL) status and macular thickness at age 18 years in the Copenhagen Prospective Studies on...

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Published in:Acta ophthalmologica (Oxford, England) England), 2023-11, Vol.101 (7), p.737-746
Main Authors: Zhu, Linna, Munch, Inger Christine, Pedersen, Casper-Emil T, Stokholm, Jakob, Bønnelykke, Klaus, Chawes, Bo, Carlsson, Christian Jakob, Schoos, Ann-Marie M, Larsen, Michael, Bisgaard, Hans, Brustad, Nicklas
Format: Article
Language:English
Subjects:
Asthma
Children
Critical period
Optic nerve
Particulate matter
Pregnancy
Smoking
Young adults
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Summary:We aimed to explore the effect of multiple pre- and postnatal exposures on optic nerve status in young adults due to this critical period for development. We analysed peripapillary retinal nerve fibre layer (RNFL) status and macular thickness at age 18 years in the Copenhagen Prospective Studies on Asthma in Childhood 2000 (COPSAC ) cohort in relation to several exposures. Of the 269 participants (median (IQR) age, 17.6 (0.6) years; 124 boys), 60 participants whose mothers had smoked during pregnancy had a thinner RNFL: adjusted mean difference -4.6 μm (95% CI -7.7; -1.5 μm, p = 0.004) compared with participants whose mothers had not smoked during pregnancy. A total of 30 participants who were exposed to tobacco smoke both during foetal life and childhood had thinner RNFL: -9.6 μm (-13.4; -5.8 μm, p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.15657