Using omics to breathe new life into our understanding of the ductus arteriosus oxygen response

The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing placentally oxygenated blood away from the developing lungs. High pulmonary vascular resistance and low systemic vascular resistance facilitate shunting of blood in utero from the pulmonary to the systemic circulat...

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Bibliographic Details
Published in:Seminars in perinatology 2023-03, Vol.47 (2), p.151715-151715, Article 151715
Main Authors: Bentley, Rachel E.T., Hindmarch, Charles C.T., Archer, Stephen L.
Format: Article
Language:English
Subjects:
DASMC
Ductus Arteriosus - physiology
Ductus Arteriosus, Patent
Egl-9 Family Hypoxia Inducible Factor 1
Heart Defects, Congenital
Humans
hypoxia
Infant, Newborn
Infant, Premature
lysyl oxidase like 2
mitochondria
multiomic analysis
Oxygen
Oxygen sensing
Patent ductus arteriosus (PDA)
Proteasome 20S Subunit Beta 1 and 6
proteomics
RNAsequencing
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Summary:The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing placentally oxygenated blood away from the developing lungs. High pulmonary vascular resistance and low systemic vascular resistance facilitate shunting of blood in utero from the pulmonary to the systemic circulation through the widely patent DA, thereby optimizing fetal oxygen (O2) delivery. With the transition from fetal (hypoxia) to neonatal (normoxia) oxygen conditions, the DA constricts while the PA dilates. This process often fails in prematurity, promoting congenital heart disease. Impaired O2-responsivness in the DA promotes persistent ductus arteriosus (PDA), the most common form of congenital heart disease. Knowledge of DA oxygen sensing has greatly advanced in the past few decades, however we still lack a complete understanding of the sensing mechanism. The genomic revolution of the past two decades has facilitated unprecedented discovery in every biological system. This review will demonstrate how multiomic integration of data generated from the DA can breathe new life into our understanding of the DA's oxygen response.
ISSN:0146-0005
1558-075X
DOI:10.1016/j.semperi.2023.151715