A Multicenter Prospective Interventional Trial of Therapeutic Angiogenesis Using Bone Marrow-Derived Mononuclear Cell Implantation for Patients With Critical Limb-Threatening Ischemia Caused by Thromboangiitis Obliterans

Background: Thromboangiitis obliterans (TAO) can lead to the development of critical limb-threatening ischemia (CLTI). Despite conventional treatments, such as smoking cessation or revascularization, young patients (

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Bibliographic Details
Published in:Circulation Journal 2023/08/25, Vol.87(9), pp.1229-1237
Main Authors: Fujioka, Ayumu, Yanishi, Kenji, Yukawa, Arito, Imai, Kojiro, Yokota, Isao, Fujikawa, Kei, Yamada, Ayumu, Naito, Akari, Shoji, Keisuke, Kawamata, Hirofumi, Higashi, Yukihito, Ishigami, Tomoaki, Sasaki, Ken-ichiro, Tara, Syuhei, Kuwahara, Koichiro, Teramukai, Satoshi, Matoba, Satoaki
Format: Article
Language:English
Subjects:
Bone Marrow
Bone Marrow Transplantation - adverse effects
Bone Marrow Transplantation - methods
Bone marrow-derived mononuclear cells
Critical limb-threatening ischemia
Female
Humans
Ischemia - etiology
Ischemia - therapy
Male
Middle Aged
Pain
Prospective Studies
Therapeutic angiogenesis
Thromboangiitis obliterans
Thromboangiitis Obliterans - therapy
Transplantation, Autologous
Treatment Outcome
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Description
Summary:Background: Thromboangiitis obliterans (TAO) can lead to the development of critical limb-threatening ischemia (CLTI). Despite conventional treatments, such as smoking cessation or revascularization, young patients (
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-23-0046