Patterns of nodal metastases, biological behaviour and prognosis of canine mast cell tumours of the pinna: A multi‐institutional retrospective study

Canine cutaneous mast cell tumours (cMCTs) of the pinna have been associated with an aggressive biological behaviour, although data remain scarce. The knowledge acquired over the past years on histologic gradings, and the value of lymph node (LN) staging, may help in better characterizing this anato...

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Published in:Veterinary & comparative oncology 2023-06, Vol.21 (2), p.332-338
Main Authors: Chalfon, Carmit, Finotello, Riccardo, Sabattini, Silvia, Gramer, Irina, Morris, Joanna Siriol, Aralla, Marina, Morello, Emanuela Maria, Ferraris, Erica, Ramos, Sofia, Polton, Gerry, Schiavo, Luca, Dobson, Jane, Cola, Veronica, Marconato, Laura
Format: Article
Language:English
Subjects:
Animals
dog
Dog Diseases - pathology
Dogs
Lymphatic Metastasis
mastocytoma
Mastocytoma, Skin - veterinary
metastasis
nodal
outcome
pinnal
Prognosis
Retrospective Studies
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Summary:Canine cutaneous mast cell tumours (cMCTs) of the pinna have been associated with an aggressive biological behaviour, although data remain scarce. The knowledge acquired over the past years on histologic gradings, and the value of lymph node (LN) staging, may help in better characterizing this anatomical presentation. The first aim was to describe the frequency, location, and histologic appearance of LN metastases in cMCT of the pinna. A second aim was to evaluate prognosis. Medical records of dogs with cMCT of the pinna, that underwent tumour and sentinel (SLN) or regional LN (RLN) excision, were reviewed. The influence of potential prognostic variables on time to progression (TTP) and tumour‐specific survival (TSS) was investigated. Thirty‐nine dogs were included: 19 (48.7%) had Kiupel high‐grade (K‐HG) and 20 (51.3%) had low‐grade (K‐LG) MCTs. Eighteen (46.1%) dogs underwent SLN mapping: the superficial cervical LN was at least one of SLN in 17 (94.4%) cases. Twenty‐two (56.4%) dogs had LN metastases; the superficial cervical LN was always involved. On multivariable analysis, only K‐HG was associated with increased risk of progression (p = .043) and tumour‐related death (p = .021). Median TTP and TSS were 270 and 370 days in K‐HG, respectively; these were not reached in dogs with K‐LG tumours (p 
ISSN:1476-5810
1476-5829
DOI:10.1111/vco.12893