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A signal “on–off-on”-type electrochemiluminescence aptamer sensor for detection of sulfadimethoxine based on Ru@Zn-oxalate MOF composites
An “on–off-on”-type electrochemiluminescence (ECL) aptamer sensor based on Ru@Zn-oxalate metal–organic framework (MOF) composites is constructed for sensitive detection of sulfadimethoxine (SDM). The prepared Ru@Zn-oxalate MOF composites with the three-dimensional structure provide good ECL performa...
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| Published in: | Mikrochimica acta (1966) 2023-04, Vol.190 (4), p.131-131, Article 131 |
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| cites | cdi_FETCH-LOGICAL-c414t-f82ec6e6edf02eaff82637210f5867b4850cbcd948f3107db860fcf4d9440f633 |
| container_end_page | 131 |
| container_issue | 4 |
| container_start_page | 131 |
| container_title | Mikrochimica acta (1966) |
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| creator | Wang, Jingjing Xu, Xuejiao Zheng, Lu Guo, Qingfu Nie, Guangming |
| description | An “on–off-on”-type electrochemiluminescence (ECL) aptamer sensor based on Ru@Zn-oxalate metal–organic framework (MOF) composites is constructed for sensitive detection of sulfadimethoxine (SDM). The prepared Ru@Zn-oxalate MOF composites with the three-dimensional structure provide good ECL performance for the “signal-on.” The MOF structure with a large surface area enables the material to fix more Ru(bpy)
3
2+
. Moreover, the Zn-oxalate MOF with three-dimensional chromophore connectivity provides a medium which can accelerate excited-state energy transfer migration among Ru(bpy)
3
2+
units, and greatly reduces the influence of solvent on chromophore, achieving a high-energy Ru emission efficiency. The aptamer chain modified with ferrocene at the end can hybridize with the capture chain DNA1 fixed on the surface of the modified electrode through base complementary pairing, which can significantly quench the ECL signal of Ru@Zn-oxalate MOF. SDM specifically binds to its aptamer to separate ferrocene from the electrode surface, resulting in a “signal-on” ECL signal. The use of the aptamer chain further improves the selectivity of the sensor. Thus, high-sensitivity detection of SDM specificity is realized through the specific affinity between SDM and its aptamer. This proposed ECL aptamer sensor has good analytical performance for SDM with low detection limit (27.3 fM) and wide detection range (100 fM–500 nM). The sensor also shows excellent stability, selectivity, and reproducibility, which proved its analytical performance. The relative standard deviation (RSD) of SDM detected by the sensor is between 2.39 and 5.32%, and the recovery is in the range 97.23 to 107.5%. The sensor shows satisfactory results in the analysis of actual seawater samples, which is expected to play a role in the exploration of marine environmental pollution.
Graphical abstract |
| doi_str_mv | 10.1007/s00604-023-05701-6 |
| format | article |
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3
2+
. Moreover, the Zn-oxalate MOF with three-dimensional chromophore connectivity provides a medium which can accelerate excited-state energy transfer migration among Ru(bpy)
3
2+
units, and greatly reduces the influence of solvent on chromophore, achieving a high-energy Ru emission efficiency. The aptamer chain modified with ferrocene at the end can hybridize with the capture chain DNA1 fixed on the surface of the modified electrode through base complementary pairing, which can significantly quench the ECL signal of Ru@Zn-oxalate MOF. SDM specifically binds to its aptamer to separate ferrocene from the electrode surface, resulting in a “signal-on” ECL signal. The use of the aptamer chain further improves the selectivity of the sensor. Thus, high-sensitivity detection of SDM specificity is realized through the specific affinity between SDM and its aptamer. This proposed ECL aptamer sensor has good analytical performance for SDM with low detection limit (27.3 fM) and wide detection range (100 fM–500 nM). The sensor also shows excellent stability, selectivity, and reproducibility, which proved its analytical performance. The relative standard deviation (RSD) of SDM detected by the sensor is between 2.39 and 5.32%, and the recovery is in the range 97.23 to 107.5%. The sensor shows satisfactory results in the analysis of actual seawater samples, which is expected to play a role in the exploration of marine environmental pollution.
Graphical abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-023-05701-6</identifier><identifier>PMID: 36912979</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analysis ; Analytical Chemistry ; Biosensing Techniques - methods ; Chains ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromophores ; Electrochemical Techniques - methods ; Electrochemiluminescence ; Electrodes ; Energy transfer ; Iron compounds ; Luminescent Measurements - methods ; Metal-organic frameworks ; Metal-Organic Frameworks - chemistry ; Metallocenes ; Microengineering ; Nanochemistry ; Nanotechnology ; Oligonucleotides ; Original Paper ; Oxalates ; Oxalic acid ; Reproducibility of Results ; Seawater ; Selectivity ; Sensors ; Stability analysis ; Sulfadimethoxine ; Three dimensional composites ; Zinc ; Zinc compounds</subject><ispartof>Mikrochimica acta (1966), 2023-04, Vol.190 (4), p.131-131, Article 131</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-f82ec6e6edf02eaff82637210f5867b4850cbcd948f3107db860fcf4d9440f633</citedby><cites>FETCH-LOGICAL-c414t-f82ec6e6edf02eaff82637210f5867b4850cbcd948f3107db860fcf4d9440f633</cites><orcidid>0000-0002-1413-2587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36912979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jingjing</creatorcontrib><creatorcontrib>Xu, Xuejiao</creatorcontrib><creatorcontrib>Zheng, Lu</creatorcontrib><creatorcontrib>Guo, Qingfu</creatorcontrib><creatorcontrib>Nie, Guangming</creatorcontrib><title>A signal “on–off-on”-type electrochemiluminescence aptamer sensor for detection of sulfadimethoxine based on Ru@Zn-oxalate MOF composites</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>An “on–off-on”-type electrochemiluminescence (ECL) aptamer sensor based on Ru@Zn-oxalate metal–organic framework (MOF) composites is constructed for sensitive detection of sulfadimethoxine (SDM). The prepared Ru@Zn-oxalate MOF composites with the three-dimensional structure provide good ECL performance for the “signal-on.” The MOF structure with a large surface area enables the material to fix more Ru(bpy)
3
2+
. Moreover, the Zn-oxalate MOF with three-dimensional chromophore connectivity provides a medium which can accelerate excited-state energy transfer migration among Ru(bpy)
3
2+
units, and greatly reduces the influence of solvent on chromophore, achieving a high-energy Ru emission efficiency. The aptamer chain modified with ferrocene at the end can hybridize with the capture chain DNA1 fixed on the surface of the modified electrode through base complementary pairing, which can significantly quench the ECL signal of Ru@Zn-oxalate MOF. SDM specifically binds to its aptamer to separate ferrocene from the electrode surface, resulting in a “signal-on” ECL signal. The use of the aptamer chain further improves the selectivity of the sensor. Thus, high-sensitivity detection of SDM specificity is realized through the specific affinity between SDM and its aptamer. This proposed ECL aptamer sensor has good analytical performance for SDM with low detection limit (27.3 fM) and wide detection range (100 fM–500 nM). The sensor also shows excellent stability, selectivity, and reproducibility, which proved its analytical performance. The relative standard deviation (RSD) of SDM detected by the sensor is between 2.39 and 5.32%, and the recovery is in the range 97.23 to 107.5%. The sensor shows satisfactory results in the analysis of actual seawater samples, which is expected to play a role in the exploration of marine environmental pollution.
Graphical abstract</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Biosensing Techniques - methods</subject><subject>Chains</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromophores</subject><subject>Electrochemical Techniques - methods</subject><subject>Electrochemiluminescence</subject><subject>Electrodes</subject><subject>Energy transfer</subject><subject>Iron compounds</subject><subject>Luminescent Measurements - methods</subject><subject>Metal-organic frameworks</subject><subject>Metal-Organic Frameworks - chemistry</subject><subject>Metallocenes</subject><subject>Microengineering</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Oligonucleotides</subject><subject>Original Paper</subject><subject>Oxalates</subject><subject>Oxalic acid</subject><subject>Reproducibility of Results</subject><subject>Seawater</subject><subject>Selectivity</subject><subject>Sensors</subject><subject>Stability analysis</subject><subject>Sulfadimethoxine</subject><subject>Three dimensional composites</subject><subject>Zinc</subject><subject>Zinc compounds</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhiMEokvhBTggS1y4uIwTx3ZurKoWkIoqIbhwsRxnvE2V2IudSO2tb8Ch1_JyfRK8zQISB2RZtme-fzSevyheMjhiAPJtAhDAKZQVhVoCo-JRsWK8ErQGWT0uVgCloJWQ5UHxLKVLACZFyZ8WB5VoWNnIZlX8WJPUb7wZyP3NXfD3N7fBObq7_KTT9RYJDminGOwFjv0wj73HZNFbJGY7mREjSehTiMTl3eGU4T54EhxJ8-BM1484XYSrLCOtSdiRnPw8v_vmabgyg5mQfDo_JTaM25D6CdPz4okzQ8IX-_Ow-Hp68uX4Az07f__xeH1GLWd8ok6VaAUK7ByUaFx-i0qWDFythGy5qsG2tmu4chUD2bVKgLOO5wgHJ6rqsHiz1N3G8H3GNOmxzx8bBuMxzEmXUomaKdbs0Nf_oJdhjnlke4orpXimjhZqYwbUvXdhisbm1eXB2eDR9Tm-lpyxBthDB-UisDGkFNHpbexHE681A73zVy_-6uyvfvBXiyx6te9lbkfs_kh-G5qBagFSTvkNxr_N_qfsL370tPo</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Wang, Jingjing</creator><creator>Xu, Xuejiao</creator><creator>Zheng, Lu</creator><creator>Guo, Qingfu</creator><creator>Nie, Guangming</creator><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1413-2587</orcidid></search><sort><creationdate>20230401</creationdate><title>A signal “on–off-on”-type electrochemiluminescence aptamer sensor for detection of sulfadimethoxine based on Ru@Zn-oxalate MOF composites</title><author>Wang, Jingjing ; Xu, Xuejiao ; Zheng, Lu ; Guo, Qingfu ; Nie, Guangming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-f82ec6e6edf02eaff82637210f5867b4850cbcd948f3107db860fcf4d9440f633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Biosensing Techniques - methods</topic><topic>Chains</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromophores</topic><topic>Electrochemical Techniques - methods</topic><topic>Electrochemiluminescence</topic><topic>Electrodes</topic><topic>Energy transfer</topic><topic>Iron compounds</topic><topic>Luminescent Measurements - methods</topic><topic>Metal-organic frameworks</topic><topic>Metal-Organic Frameworks - chemistry</topic><topic>Metallocenes</topic><topic>Microengineering</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Oligonucleotides</topic><topic>Original Paper</topic><topic>Oxalates</topic><topic>Oxalic acid</topic><topic>Reproducibility of Results</topic><topic>Seawater</topic><topic>Selectivity</topic><topic>Sensors</topic><topic>Stability analysis</topic><topic>Sulfadimethoxine</topic><topic>Three dimensional composites</topic><topic>Zinc</topic><topic>Zinc compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jingjing</creatorcontrib><creatorcontrib>Xu, Xuejiao</creatorcontrib><creatorcontrib>Zheng, Lu</creatorcontrib><creatorcontrib>Guo, Qingfu</creatorcontrib><creatorcontrib>Nie, Guangming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jingjing</au><au>Xu, Xuejiao</au><au>Zheng, Lu</au><au>Guo, Qingfu</au><au>Nie, Guangming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A signal “on–off-on”-type electrochemiluminescence aptamer sensor for detection of sulfadimethoxine based on Ru@Zn-oxalate MOF composites</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>190</volume><issue>4</issue><spage>131</spage><epage>131</epage><pages>131-131</pages><artnum>131</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>An “on–off-on”-type electrochemiluminescence (ECL) aptamer sensor based on Ru@Zn-oxalate metal–organic framework (MOF) composites is constructed for sensitive detection of sulfadimethoxine (SDM). The prepared Ru@Zn-oxalate MOF composites with the three-dimensional structure provide good ECL performance for the “signal-on.” The MOF structure with a large surface area enables the material to fix more Ru(bpy)
3
2+
. Moreover, the Zn-oxalate MOF with three-dimensional chromophore connectivity provides a medium which can accelerate excited-state energy transfer migration among Ru(bpy)
3
2+
units, and greatly reduces the influence of solvent on chromophore, achieving a high-energy Ru emission efficiency. The aptamer chain modified with ferrocene at the end can hybridize with the capture chain DNA1 fixed on the surface of the modified electrode through base complementary pairing, which can significantly quench the ECL signal of Ru@Zn-oxalate MOF. SDM specifically binds to its aptamer to separate ferrocene from the electrode surface, resulting in a “signal-on” ECL signal. The use of the aptamer chain further improves the selectivity of the sensor. Thus, high-sensitivity detection of SDM specificity is realized through the specific affinity between SDM and its aptamer. This proposed ECL aptamer sensor has good analytical performance for SDM with low detection limit (27.3 fM) and wide detection range (100 fM–500 nM). The sensor also shows excellent stability, selectivity, and reproducibility, which proved its analytical performance. The relative standard deviation (RSD) of SDM detected by the sensor is between 2.39 and 5.32%, and the recovery is in the range 97.23 to 107.5%. The sensor shows satisfactory results in the analysis of actual seawater samples, which is expected to play a role in the exploration of marine environmental pollution.
Graphical abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>36912979</pmid><doi>10.1007/s00604-023-05701-6</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1413-2587</orcidid></addata></record> |
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| subjects | Analysis Analytical Chemistry Biosensing Techniques - methods Chains Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromophores Electrochemical Techniques - methods Electrochemiluminescence Electrodes Energy transfer Iron compounds Luminescent Measurements - methods Metal-organic frameworks Metal-Organic Frameworks - chemistry Metallocenes Microengineering Nanochemistry Nanotechnology Oligonucleotides Original Paper Oxalates Oxalic acid Reproducibility of Results Seawater Selectivity Sensors Stability analysis Sulfadimethoxine Three dimensional composites Zinc Zinc compounds |
| title | A signal “on–off-on”-type electrochemiluminescence aptamer sensor for detection of sulfadimethoxine based on Ru@Zn-oxalate MOF composites |
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