Effect of the BMP on the Degradability of the Porous Calcium Phosphate Bioceramic in vivo

• Published in: Key engineering materials 2003-01, Vol.249, p.441-446
• Main Authors: Liang, S.F., Ming, L., Huang, Xue Hui, Bing, S.X.
• Format: Article
• Language: English
• ISSN: 1013-9826; 1662-9795; 1662-9795
• DOI: 10.4028/www.scientific.net/KEM.249.441

The biodegradability, osteogenesis effect of calcium phosphate porous ceramic (CP) and the bone morphogenetic protein(BMP)-calcium phosphate composite (BCP) as well as the microstructure of the boundary between the material above and bone were studied by the X-ray photography, SEM, and EPMA techniques. The statistic T examination was used to dispose the data of the rate of new bone forming after two kinds of materialsCP and BCP had been embedded into body. The results show that the rate of new bone forming of BCP is obviously higher than that of CP. BMP evidently accelerates the formation of the new bone and the degradation of the calcium phosphate mineral. The porous structure also contributes to the mineral degradation and the new bone formation. The new bone which grows into the pores of the ceramics forms a kind of interpenetrating network structure, and it strengthens the mechanical properties of embedded part and compensates the attenuation of mechanical properties resulted from the degradation. Therefore, it is evident that a kind of biomaterial can be prepared, which can completely degrade in a suitable pore structure and by the osteogenesis abduction mechanism.