Effects of Lactobacillus acidophilus administration to anorexigenic neuropeptides and some biochemical parameters on rats fed with a high-fat diet

One of the rapidly rising global public health concern is obesity. Over the past three decades, the prevalence of obesity has doubled/tripled in several nations around the world, most likely as a result of urbanization, sedentary lifestyles, and increased intake of high-calorie processed foods. In t...

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Published in:Prostaglandins & other lipid mediators 2023-06, Vol.166, p.106729-106729, Article 106729
Main Authors: Çayli, Berna, Çiftci, Gülay, Çiftci, Alper, Savaşan, Sadık
Format: Article
Language:English
Subjects:
Animals
Anorexigenic peptid
Diet, High-Fat - adverse effects
Glucagon-Like Peptide 1
Glucose
Lactobacillus acidophilus
Leptin
Neuropeptides
Obesity
Obesity - etiology
Probiotics - pharmacology
Rats
Serotonin
Triglycerides
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Summary:One of the rapidly rising global public health concern is obesity. Over the past three decades, the prevalence of obesity has doubled/tripled in several nations around the world, most likely as a result of urbanization, sedentary lifestyles, and increased intake of high-calorie processed foods. In this study, it was aimed to investigate the effects of Lactobacillus acidophilus administration on rats exposed to high-fat diet experimentally on anorexigenic peptides in the brain and some biochemical parameters in the serum. In the study, 4 different experimental groups were formed. Group 1 was designated as the control group and fed with a standard rat chow (SD). Group 2 was designated as the high-fat diet (HFD) fed group. Group 3 fed with SD and L. acidophilus probiotic administered. Group 4 fed with HFD and L. acidophilus probiotic administered. At the end of the experiment, leptin, serotonin, glucagon-like peptide-1 (GLP-1) levels were measured in the brain tissue and serum. Glucose, total cholesterol (TC), triglyceride (TG), total protein (TP), albumin, uric acid, aspartate transaminase (AST), alanine aminotransferase (ALT) levels were determined in the serum. At the end of the study, it was found that there was an increase in body weight and body mass index in Group 2 compared to Group 1. It was determined that the levels of AST, ALT, TG, TC, glucose, leptin in the serum were significantly high (P 
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2023.106729