A multi-omics view of neuronal subcellular protein synthesis

While it has long been known that protein synthesis is necessary for long-term memory in the brain, the logistics of neuronal protein synthesis is complicated by the extensive subcellular compartmentalization of the neuron. Local protein synthesis solves many of the logistic problems posed by the ex...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in neurobiology 2023-06, Vol.80, p.102705-102705, Article 102705
Main Authors: Sun, Chao, Schuman, Erin
Format: Article
Language:English
Subjects:
Axons
Multiomics
Neurons - physiology
Protein Biosynthesis
Proteomics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:While it has long been known that protein synthesis is necessary for long-term memory in the brain, the logistics of neuronal protein synthesis is complicated by the extensive subcellular compartmentalization of the neuron. Local protein synthesis solves many of the logistic problems posed by the extreme complexity of dendritic and axonal arbors and the huge number of synapses. Here we review recent multi-omic and quantitative studies that elaborate a systems view of decentralized neuronal protein synthesis. We highlight recent insights from the transcriptomic, translatomic, and proteomic levels, discuss the nuanced logic of local protein synthesis for different protein features, and list the missing information needed to build a comprehensive logistic model for neuronal protein supply. •Neuronal subcellular multi-omics are beginning to provide a quantitative picture of mRNAs, machines, and protein products.•Distinct transcript preference, translational mode, and ribosome dynamics are features of local translation.•The logic of local protein synthesis is emerging.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2023.102705