Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratios Are Prognostic Markers for Pheochromocytomas and Paragangliomas

Abstract Context Preoperative inflammatory markers, such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), have recently been proposed as prognostic markers in different tumors. However, their predictive values in patients with pheochromo...

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Published in:The journal of clinical endocrinology and metabolism 2023-08, Vol.108 (9), p.2230-2239
Main Authors: Zhong, Xu, Su, TingWei, Yang, Yifan, Ye, Lei, Jiang, Lei, Qi, Yan, Xie, Jing, Jiang, Yiran, Zhou, Weiwei, Zhang, Cui, Wu, Luming, Zhu, Hongyuan, Ning, Guang, Wang, Weiqing
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Language:English
Subjects:
Inflammation
Leukocytes (neutrophilic)
Lymphocytes
Medical prognosis
Metastases
Monocytes
Neutrophils
Paraganglioma
Platelets
Regression analysis
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cited_by cdi_FETCH-LOGICAL-c334t-927f418565c093d3e50c7f2082adc8b0edd51560ab4ad92c05ea356578dbd9a13
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container_issue 9
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container_title The journal of clinical endocrinology and metabolism
container_volume 108
creator Zhong, Xu
Su, TingWei
Yang, Yifan
Ye, Lei
Jiang, Lei
Qi, Yan
Xie, Jing
Jiang, Yiran
Zhou, Weiwei
Zhang, Cui
Wu, Luming
Zhu, Hongyuan
Ning, Guang
Wang, Weiqing
description Abstract Context Preoperative inflammatory markers, such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), have recently been proposed as prognostic markers in different tumors. However, their predictive values in patients with pheochromocytomas and paragangliomas (PPGLs) are uncertain. Objective This study aimed to investigate the prognostic significance of inflammatory biomarkers in PPGL patients. Methods Data from 1247 consecutive PPGL patients between 2002 and 2020 were evaluated. The preoperative inflammatory markers were evaluated. The prognostic roles were identified by X-tile software, Kaplan-Meier curves, and Cox regression models. Results A total of 728 patients were included in the analysis, with a median follow-up of 63 months (IQR, 31-111 months); 31 individuals died, 28 patients developed metastases, and 12 patients developed recurrence. Our study showed that deaths were observed significantly more frequently in patients with high NLR(≥3.5) and high PLR (≥217.4) than those with low NLR (
doi_str_mv 10.1210/clinem/dgad149
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However, their predictive values in patients with pheochromocytomas and paragangliomas (PPGLs) are uncertain. Objective This study aimed to investigate the prognostic significance of inflammatory biomarkers in PPGL patients. Methods Data from 1247 consecutive PPGL patients between 2002 and 2020 were evaluated. The preoperative inflammatory markers were evaluated. The prognostic roles were identified by X-tile software, Kaplan-Meier curves, and Cox regression models. Results A total of 728 patients were included in the analysis, with a median follow-up of 63 months (IQR, 31-111 months); 31 individuals died, 28 patients developed metastases, and 12 patients developed recurrence. Our study showed that deaths were observed significantly more frequently in patients with high NLR(≥3.5) and high PLR (≥217.4) than those with low NLR (&lt;3.5) (P = .003) and low PLR (&lt;217.4) (P = .005). Elevated NLR (≥3.5) and elevated PLR (≥217.4) was significantly associated with decreased overall survival (OS) (P = .005), and elevated PLR (≥238.3) was significantly associated with decreased metastasis-free survival (MFS) (P = .021). Cox models illustrated that NLR and PLR were independent prognostic factors for OS, and PLR was an independent prognostic factor for MFS. Conclusion Both elevated NLR and PLR are associated with poor prognosis in PPGLs. They are convenient predictive markers that could be used in daily clinical practice.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgad149</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Inflammation ; Leukocytes (neutrophilic) ; Lymphocytes ; Medical prognosis ; Metastases ; Monocytes ; Neutrophils ; Paraganglioma ; Platelets ; Regression analysis</subject><ispartof>The journal of clinical endocrinology and metabolism, 2023-08, Vol.108 (9), p.2230-2239</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-927f418565c093d3e50c7f2082adc8b0edd51560ab4ad92c05ea356578dbd9a13</citedby><cites>FETCH-LOGICAL-c334t-927f418565c093d3e50c7f2082adc8b0edd51560ab4ad92c05ea356578dbd9a13</cites><orcidid>0000-0001-6027-3084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhong, Xu</creatorcontrib><creatorcontrib>Su, TingWei</creatorcontrib><creatorcontrib>Yang, Yifan</creatorcontrib><creatorcontrib>Ye, Lei</creatorcontrib><creatorcontrib>Jiang, Lei</creatorcontrib><creatorcontrib>Qi, Yan</creatorcontrib><creatorcontrib>Xie, Jing</creatorcontrib><creatorcontrib>Jiang, Yiran</creatorcontrib><creatorcontrib>Zhou, Weiwei</creatorcontrib><creatorcontrib>Zhang, Cui</creatorcontrib><creatorcontrib>Wu, Luming</creatorcontrib><creatorcontrib>Zhu, Hongyuan</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><title>Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratios Are Prognostic Markers for Pheochromocytomas and Paragangliomas</title><title>The journal of clinical endocrinology and metabolism</title><description>Abstract Context Preoperative inflammatory markers, such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), have recently been proposed as prognostic markers in different tumors. However, their predictive values in patients with pheochromocytomas and paragangliomas (PPGLs) are uncertain. Objective This study aimed to investigate the prognostic significance of inflammatory biomarkers in PPGL patients. Methods Data from 1247 consecutive PPGL patients between 2002 and 2020 were evaluated. The preoperative inflammatory markers were evaluated. The prognostic roles were identified by X-tile software, Kaplan-Meier curves, and Cox regression models. Results A total of 728 patients were included in the analysis, with a median follow-up of 63 months (IQR, 31-111 months); 31 individuals died, 28 patients developed metastases, and 12 patients developed recurrence. Our study showed that deaths were observed significantly more frequently in patients with high NLR(≥3.5) and high PLR (≥217.4) than those with low NLR (&lt;3.5) (P = .003) and low PLR (&lt;217.4) (P = .005). Elevated NLR (≥3.5) and elevated PLR (≥217.4) was significantly associated with decreased overall survival (OS) (P = .005), and elevated PLR (≥238.3) was significantly associated with decreased metastasis-free survival (MFS) (P = .021). Cox models illustrated that NLR and PLR were independent prognostic factors for OS, and PLR was an independent prognostic factor for MFS. Conclusion Both elevated NLR and PLR are associated with poor prognosis in PPGLs. 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However, their predictive values in patients with pheochromocytomas and paragangliomas (PPGLs) are uncertain. Objective This study aimed to investigate the prognostic significance of inflammatory biomarkers in PPGL patients. Methods Data from 1247 consecutive PPGL patients between 2002 and 2020 were evaluated. The preoperative inflammatory markers were evaluated. The prognostic roles were identified by X-tile software, Kaplan-Meier curves, and Cox regression models. Results A total of 728 patients were included in the analysis, with a median follow-up of 63 months (IQR, 31-111 months); 31 individuals died, 28 patients developed metastases, and 12 patients developed recurrence. Our study showed that deaths were observed significantly more frequently in patients with high NLR(≥3.5) and high PLR (≥217.4) than those with low NLR (&lt;3.5) (P = .003) and low PLR (&lt;217.4) (P = .005). Elevated NLR (≥3.5) and elevated PLR (≥217.4) was significantly associated with decreased overall survival (OS) (P = .005), and elevated PLR (≥238.3) was significantly associated with decreased metastasis-free survival (MFS) (P = .021). Cox models illustrated that NLR and PLR were independent prognostic factors for OS, and PLR was an independent prognostic factor for MFS. Conclusion Both elevated NLR and PLR are associated with poor prognosis in PPGLs. They are convenient predictive markers that could be used in daily clinical practice.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1210/clinem/dgad149</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6027-3084</orcidid></addata></record>
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subjects Inflammation
Leukocytes (neutrophilic)
Lymphocytes
Medical prognosis
Metastases
Monocytes
Neutrophils
Paraganglioma
Platelets
Regression analysis
title Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratios Are Prognostic Markers for Pheochromocytomas and Paragangliomas
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