Palladium-catalysed site-selective arene ortho C-H fluoroalkoxylation of 4-aryl-pyrrolo[2,3- d ]pyrimidines

A palladium-catalysed direct arene C-H fluoroalkoxylation of 4-aryl-pyrrolo[2,3- ]pyrimidine derivatives with fluorinated alcohols is described. Highly site-selective mono- or bis-fluoroalkoxylation can be achieved by tuning the reaction conditions, affording various fluoroalkoxylated pyrrolo[2,3- ]...

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Published in:Organic & biomolecular chemistry 2023-03, Vol.21 (13), p.2748-2753
Main Authors: Jiang, Yunfeng, Pan, Chenhong, Tang, Ting, Liu, Mingrui, Zhang, Xingxian
Format: Article
Language:English
Subjects:
Alcohols
Aromatic compounds
Biological activity
Palladium
Pyrimidines
Pyrrolo[2,3-d]Pyrimidines
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creator Jiang, Yunfeng
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description A palladium-catalysed direct arene C-H fluoroalkoxylation of 4-aryl-pyrrolo[2,3- ]pyrimidine derivatives with fluorinated alcohols is described. Highly site-selective mono- or bis-fluoroalkoxylation can be achieved by tuning the reaction conditions, affording various fluoroalkoxylated pyrrolo[2,3- ]pyrimidine derivatives in moderate to good yields, which offer rational tailoring of their biological activity for their application in the field of pharmaceutical chemistry.
doi_str_mv 10.1039/d3ob00084b
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source Royal Society of Chemistry
subjects Alcohols
Aromatic compounds
Biological activity
Palladium
Pyrimidines
Pyrrolo[2,3-d]Pyrimidines
title Palladium-catalysed site-selective arene ortho C-H fluoroalkoxylation of 4-aryl-pyrrolo[2,3- d ]pyrimidines
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