Neural Network Functional Interactions Mediate or Suppress White Matter–Emotional Behavior Relationships in Infants

• Published in: Biological psychiatry (1969) 2023-07, Vol.94 (1), p.57-67
• Main Authors: Banihashemi, Layla, Schmithorst, Vanessa J., Bertocci, Michele A., Samolyk, Alyssa, Zhang, Yicheng, Lima Santos, João Paulo, Versace, Amelia, Taylor, Megan, English, Gabrielle, Northrup, Jessie B., Lee, Vincent K., Stiffler, Richelle, Aslam, Haris, Panigrahy, Ashok, Hipwell, Alison E., Phillips, Mary L.
• Format: Article
• Language: English
• Subjects: Brain - diagnostic imaging; Brain - pathology; Diffusion Magnetic Resonance Imaging; Diffusion-weighted imaging; Female; Humans; Infant; Infant brain; Infant emotionality; Magnetic Resonance Imaging - methods; Male; Mediation; Multimodal; Neural Networks, Computer; Neural Pathways; Resting-state; White Matter - pathology
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2023.03.004

Elucidating the neural basis of infant positive emotionality and negative emotionality can identify biomarkers of pathophysiological risk. Our goal was to determine how functional interactions among large-scale networks supporting emotional regulation influence white matter (WM) microstructural–emotional behavior relationships in 3-month-old infants. We hypothesized that microstructural–emotional behavior relationships would be differentially mediated or suppressed by underlying resting-state functional connectivity (rsFC), particularly between default mode network and central executive network structures. The analytic sample comprised primary caregiver–infant dyads (52 infants [42% female, mean age at scan = 15.10 weeks]), with infant neuroimaging and emotional behavior assessments conducted at 3 months. Infant WM and rsFC were assessed by diffusion-weighted imaging/tractography and resting-state magnetic resonance imaging during natural, nonsedated sleep. The Infant Behavior Questionnaire-Revised provided measures of infant positive emotionality and negative emotionality. After significant WM–emotional behavior relationships were observed, multimodal analyses were performed using whole-brain voxelwise mediation. Results revealed that greater cingulum bundle volume was significantly associated with lower infant positive emotionality (β = −0.263, p = .031); however, a pattern of lower rsFC between central executive network and default mode network structures suppressed this otherwise negative relationship. Greater uncinate fasciculus volume was significantly associated with lower infant negative emotionality (β = −0.296, p = .022); however, lower orbitofrontal cortex–amygdala rsFC suppressed this otherwise negative relationship, while greater orbitofrontal cortex–central executive network rsFC mediated this relationship. Functional interactions among neural networks have an important influence on WM microstructural–emotional behavior relationships in infancy. These relationships can elucidate neural mechanisms that contribute to future behavioral and emotional problems in childhood.