Caring for two in the ICU: Pharmacotherapy in the critically ill pregnant patient

• Published in: Pharmacotherapy 2023-05, Vol.43 (5), p.403-418
• Main Authors: Heavner, Mojdeh S., Erdman, Grace, Barlow, Brooke, Aldhaeefi, Mohammed, Cucci, Michaelia, Eng, Claire C., Hawkins, W. Anthony, Rose, Christina, Smith, Susan E., Bell, Carolyn Magee, Lankford, Allison, Li, Matthew, Thompson Bastin, Melissa L.
• Format: Article
• Language: English
• Subjects: Coronaviruses; Critical care; Critical Care - methods; Critical Illness - epidemiology; Drug metabolism; Drug therapy; Female; Fetuses; Gastric emptying; Gestational age; Humans; Intensive Care Units; Metabolism; Pharmacokinetics; Placenta; Pregnancy; pregnancy complications; Pregnancy Complications - drug therapy; Respiratory distress syndrome; Sepsis; Thromboembolism
• ISSN: 0277-0008; 1875-9114
• DOI: 10.1002/phar.2795

Safe and thoughtful medication management of pregnant patients requiring intensive care unit (ICU) level of care is key to optimizing outcomes for both mother and fetus. Pregnancy induces physiologic alterations that closely mirror the changes expected in a critically ill patient. These changes can be predictable depending on the gestational age and trimester and will directly impact the pharmacokinetic profile of medications commonly used in the ICU; examples include decreased gastric emptying, increased blood and plasma volume, increased glomerular filtration, and increased cardiac output. When pregnant patients require ICU care, the resulting impact on drug absorption, distribution, metabolism, and elimination can be difficult to predict. In addition, there are many nuances of medication metabolism and interface with the placental barrier that should be considered when selecting pharmacotherapy for the pregnant patient. Critical care clinicians need to be aware of medication interactions with the placenta and weigh the risk versus benefit profile of medication use in this patient population. Obstetric critical care admissions have increased over the years, especially during the coronavirus waves. Therefore, understanding the interplay between pregnancy and critical illness to optimize pharmacotherapy selection is crucial to improving health outcomes of mother and fetus. This review highlights pharmacotherapy considerations in the pregnant ICU patient for the following topics: physiologic alterations, categorizing medication risk, supportive care, sepsis, cardiogenic shock, acute respiratory distress syndrome, and venous thromboembolism.