Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability

The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative ag...

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Published in:Biomedicine & pharmacotherapy 2022-10, Vol.154, p.113642-113642, Article 113642
Main Authors: Grujić-Milanović, Jelica, Jaćević, Vesna, Miloradović, Zoran, Milanović, Sladjan D, Jovović, Djurdjica, Ivanov, Milan, Karanović, Danijela, Vajić, Una-Jovana, Mihailović-Stanojević, Nevena
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Biological Availability
Blood Pressure
Hypertension - metabolism
Hypertension, Malignant - drug therapy
Hypertension, Malignant - metabolism
Hypertension, Malignant - pathology
Kidney - pathology
NG-Nitroarginine Methyl Ester - metabolism
Nitric Oxide - metabolism
Oxidative Stress
Rats
Rats, Inbred SHR
Resveratrol - pharmacology
Resveratrol - therapeutic use
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Summary:The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties. In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in N -L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR). Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2022.113642