Relationship between rs4349859 and rs116488202 polymorphisms close to MHC-I region and serum urate levels in patients with gout

Background Gout is the most common inflammatory rheumatic disease and elevated levels of serum urate (SU) are the main cause for its development. Major histocompatibility complex class 1 (MHC-1) plays an important role in the development of multiple inflammatory diseases; however, there is little ev...

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Published in:Molecular biology reports 2023-05, Vol.50 (5), p.4367-4374
Main Authors: Fernández-Torres, Javier, Zamudio-Cuevas, Yessica, Martínez-Nava, Gabriela Angélica, Martínez-Flores, Karina, Ruíz-Dávila, Xiadani, Sánchez-Sánchez, Roberto
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Gout
Gout - genetics
Heterozygote
Histology
Humans
Inflammatory diseases
Life Sciences
Major histocompatibility complex
Morphology
Original Article
Polymorphism, Single Nucleotide - genetics
Single-nucleotide polymorphism
Uric Acid
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Summary:Background Gout is the most common inflammatory rheumatic disease and elevated levels of serum urate (SU) are the main cause for its development. Major histocompatibility complex class 1 (MHC-1) plays an important role in the development of multiple inflammatory diseases; however, there is little evidence of its involvement in gout. The present study focused on evaluating the association of the rs4349859 and rs116488202 single nucleotide polymorphisms (SNPs) close to the MHC-1 region in patients with gout. Methods and results One hundred and seventy-six individuals of Mexican origin were included, of which 81 were patients with primary gout and 95 were healthy controls. The rs4349859 and rs116488202 SNPs were genotyped using TaqMan probes by allelic discrimination by real-time PCR. Serum concentrations of biochemical parameters were measured with enzymatic methods. Descriptive statistics were applied and P -values 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08359-8