Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature

Meta-analysis. To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis. Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have show...

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Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 2023-05, Vol.48 (10), p.695-701
Main Authors: AlMekkawi, Ahmad K., Caruso, James P., El Ahmadieh, Tarek Y., Palmisciano, Paolo, Aljardali, Marwa W., Derian, Armen G., Al Tamimi, Mazin, Bagley, Carlos A., Aoun, Salah G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Genetic Predisposition to Disease - genetics
Genotype
Homeodomain Proteins - genetics
Humans
Polymorphism, Single Nucleotide - genetics
Scoliosis - diagnosis
Scoliosis - genetics
Transcription Factors - genetics
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Summary:Meta-analysis. To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis. Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS. Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P
ISSN:0362-2436
1528-1159
DOI:10.1097/BRS.0000000000004623