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Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature
Meta-analysis. To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis. Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have show...
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| Published in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2023-05, Vol.48 (10), p.695-701 |
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| container_end_page | 701 |
| container_issue | 10 |
| container_start_page | 695 |
| container_title | Spine (Philadelphia, Pa. 1976) |
| container_volume | 48 |
| creator | AlMekkawi, Ahmad K. Caruso, James P. El Ahmadieh, Tarek Y. Palmisciano, Paolo Aljardali, Marwa W. Derian, Armen G. Al Tamimi, Mazin Bagley, Carlos A. Aoun, Salah G. |
| description | Meta-analysis.
To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis.
Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS.
Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P |
| doi_str_mv | 10.1097/BRS.0000000000004623 |
| format | article |
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To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis.
Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS.
Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P <0.05. The final analysis paper's quality was evaluated using the Newcastle Ottawa Scale. Kappa interrater agreement was calculated to evaluate the agreement between authors.
The final analysis comprised 43 publications, 19412 cases, 22005 controls, and 25 distinct genes. LBX1 rs11190870 T>C and MATN-1 SNPs were associated with an increased risk of AIS in one or all of the 5 genetic models. IGF-1 , estrogen receptor alfa, and MTNR1B , SNPs were not associated with AIS in all 5 genetic models. Newcastle Ottawa Scale showed good quality for the selected articles. Cohen k = 0.741 and Kappa interrater agreement of 84% showed that the writers were in strong agreement.
There seem to be associations between AIS and genetic SNP. Further larger studies should be conducted to validate the results.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/BRS.0000000000004623</identifier><identifier>PMID: 36940245</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Genetic Predisposition to Disease - genetics ; Genotype ; Homeodomain Proteins - genetics ; Humans ; Polymorphism, Single Nucleotide - genetics ; Scoliosis - diagnosis ; Scoliosis - genetics ; Transcription Factors - genetics</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2023-05, Vol.48 (10), p.695-701</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3015-80d9448e1a59804fce55d88661910a903930f54038e1327c57899a6d7b3639473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36940245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AlMekkawi, Ahmad K.</creatorcontrib><creatorcontrib>Caruso, James P.</creatorcontrib><creatorcontrib>El Ahmadieh, Tarek Y.</creatorcontrib><creatorcontrib>Palmisciano, Paolo</creatorcontrib><creatorcontrib>Aljardali, Marwa W.</creatorcontrib><creatorcontrib>Derian, Armen G.</creatorcontrib><creatorcontrib>Al Tamimi, Mazin</creatorcontrib><creatorcontrib>Bagley, Carlos A.</creatorcontrib><creatorcontrib>Aoun, Salah G.</creatorcontrib><title>Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>Meta-analysis.
To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis.
Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS.
Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P <0.05. The final analysis paper's quality was evaluated using the Newcastle Ottawa Scale. Kappa interrater agreement was calculated to evaluate the agreement between authors.
The final analysis comprised 43 publications, 19412 cases, 22005 controls, and 25 distinct genes. LBX1 rs11190870 T>C and MATN-1 SNPs were associated with an increased risk of AIS in one or all of the 5 genetic models. IGF-1 , estrogen receptor alfa, and MTNR1B , SNPs were not associated with AIS in all 5 genetic models. Newcastle Ottawa Scale showed good quality for the selected articles. Cohen k = 0.741 and Kappa interrater agreement of 84% showed that the writers were in strong agreement.
There seem to be associations between AIS and genetic SNP. Further larger studies should be conducted to validate the results.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Scoliosis - diagnosis</subject><subject>Scoliosis - genetics</subject><subject>Transcription Factors - genetics</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkVtv1DAQhS0EotvCP6iQH3lJ63ts3paKXqSFVl14jtxk0hiceGs7rFbix-PeADEvI42-c0ZzBqFDSo4oMfXxx-v1EfmnhGL8BVpQyXRFqTQv0YJwxSomuNpD-yl9L5Di1LxGe1wZQZiQC_Rr7aZbD_jL3HoI2XWAr4LfjSFuBpfGhO3U4WUXPKQWpowvOhc2Ng-uxes2eBeSSx_wEq93KcNoc5lfw08H2wfhZ8i2Wk7W7wqGQ4_zAHjlMkSb5whv0Kve-gRvn_oB-nb66evJebW6PLs4Wa6qlhMqK006I4QGaqXRRPQtSNlprRQ1lFhDuOGkl4LwgnBWt7LWxljV1TdccSNqfoDeP_puYribIeVmdOUc7-0EYU4NKwLGVa11QcUj2saQUoS-2UQ32rhrKGnuc29K7s3_uRfZu6cN880I3R_Rc9B_fbfBl_PTDz9vITYDWJ-HB79a8fIswjiRVJLqfiT5b-IdjNs</recordid><startdate>20230515</startdate><enddate>20230515</enddate><creator>AlMekkawi, Ahmad K.</creator><creator>Caruso, James P.</creator><creator>El Ahmadieh, Tarek Y.</creator><creator>Palmisciano, Paolo</creator><creator>Aljardali, Marwa W.</creator><creator>Derian, Armen G.</creator><creator>Al Tamimi, Mazin</creator><creator>Bagley, Carlos A.</creator><creator>Aoun, Salah G.</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230515</creationdate><title>Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature</title><author>AlMekkawi, Ahmad K. ; Caruso, James P. ; El Ahmadieh, Tarek Y. ; Palmisciano, Paolo ; Aljardali, Marwa W. ; Derian, Armen G. ; Al Tamimi, Mazin ; Bagley, Carlos A. ; Aoun, Salah G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3015-80d9448e1a59804fce55d88661910a903930f54038e1327c57899a6d7b3639473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Homeodomain Proteins - genetics</topic><topic>Humans</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Scoliosis - diagnosis</topic><topic>Scoliosis - genetics</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AlMekkawi, Ahmad K.</creatorcontrib><creatorcontrib>Caruso, James P.</creatorcontrib><creatorcontrib>El Ahmadieh, Tarek Y.</creatorcontrib><creatorcontrib>Palmisciano, Paolo</creatorcontrib><creatorcontrib>Aljardali, Marwa W.</creatorcontrib><creatorcontrib>Derian, Armen G.</creatorcontrib><creatorcontrib>Al Tamimi, Mazin</creatorcontrib><creatorcontrib>Bagley, Carlos A.</creatorcontrib><creatorcontrib>Aoun, Salah G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AlMekkawi, Ahmad K.</au><au>Caruso, James P.</au><au>El Ahmadieh, Tarek Y.</au><au>Palmisciano, Paolo</au><au>Aljardali, Marwa W.</au><au>Derian, Armen G.</au><au>Al Tamimi, Mazin</au><au>Bagley, Carlos A.</au><au>Aoun, Salah G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2023-05-15</date><risdate>2023</risdate><volume>48</volume><issue>10</issue><spage>695</spage><epage>701</epage><pages>695-701</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><abstract>Meta-analysis.
To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis.
Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS.
Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P <0.05. The final analysis paper's quality was evaluated using the Newcastle Ottawa Scale. Kappa interrater agreement was calculated to evaluate the agreement between authors.
The final analysis comprised 43 publications, 19412 cases, 22005 controls, and 25 distinct genes. LBX1 rs11190870 T>C and MATN-1 SNPs were associated with an increased risk of AIS in one or all of the 5 genetic models. IGF-1 , estrogen receptor alfa, and MTNR1B , SNPs were not associated with AIS in all 5 genetic models. Newcastle Ottawa Scale showed good quality for the selected articles. Cohen k = 0.741 and Kappa interrater agreement of 84% showed that the writers were in strong agreement.
There seem to be associations between AIS and genetic SNP. Further larger studies should be conducted to validate the results.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>36940245</pmid><doi>10.1097/BRS.0000000000004623</doi><tpages>7</tpages></addata></record> |
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| ispartof | Spine (Philadelphia, Pa. 1976), 2023-05, Vol.48 (10), p.695-701 |
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| source | HEAL-Link subscriptions: Lippincott Williams & Wilkins |
| subjects | Adolescent Adult Genetic Predisposition to Disease - genetics Genotype Homeodomain Proteins - genetics Humans Polymorphism, Single Nucleotide - genetics Scoliosis - diagnosis Scoliosis - genetics Transcription Factors - genetics |
| title | Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature |
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