Prognostic role and predictors of lymph node involvement in pancreatic neuroendocrine tumors

• Published in: European journal of radiology 2023-05, Vol.162, p.110772-110772, Article 110772
• Main Authors: Ren, Shu-Jie, Tan, Qing-Quan, Cao, Dan, Ke, Neng-Wen, Liu, Xu-Bao, Wang, Xing
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Lymph node involvement; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Male; Middle Aged; Neuroendocrine Tumors - diagnostic imaging; Neuroendocrine Tumors - surgery; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - surgery; Pancreatic neuroendocrine tumor; Prognosis; Prognostic factor; Radiologic characteristic; Retrospective Studies; Young Adult
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2023.110772

To define the prognostic role of lymph node involvement (LNI) in patients with pancreatic neuroendocrine tumors (PNETs) and identify predictors of LNI using a comprehensive multifactor analysis focusing on preoperative radiological features. This study included 236 patients with preoperative computed tomography who underwent radical surgical resection of PNETs at our hospital between 2009 and 2019. Univariate and multivariable logistic regression analyses were performed to investigate the risk factors associated with LNI and tumor recurrence. The disease-free survival (DFS) rates with and without LNI were compared. Forty-four of the 236 patients (18.6%) had LNI. Biliopancreatic duct dilatation (odds ratio [OR], 2.295; 95% confidence interval [CI], 1.046–5.035; p = 0.038), tumor margin (OR, 2.189; 95% CI, 1.034–4.632; p = 0.041), and WHO grade (G2: OR, 2.923; 95% CI, 1.005–8.507; p = 0.049; G3: OR, 12.067; 95% CI, 3.057–47.629; p