Hypertriglyceridemic waist phenotype, hypertriglyceridemic waist-to-height ratio phenotype and abnormal glucose metabolism in adolescents

The purpose of this study was to evaluate the relationship between hypertriglyceridemic waist (HW) phenotype,hypertriglyceridemic waist-to-height ratio (HWHtR) phenotype and abnormal glucose metabolism in adolescents. A secondary analysis was conducted on 2626 adolescents aged 12–19 years in United...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes research and clinical practice 2023-04, Vol.198, p.110622-110622, Article 110622
Main Authors: Lu, Na, Cheng, Gang, Ma, Chun-Ming, Liu, Xiao-Li
Format: Article
Language:English
Subjects:
Abnormal glucose metabolism
Adolescents
Blood Glucose
Glucose
Humans
Hypertriglyceridemic Waist - complications
Hypertriglyceridemic Waist - epidemiology
Hypertriglyceridemic waist phenotype
Hypertriglyceridemic waist-to-height ratio phenotype
Insulin Resistance
Phenotype
Risk Factors
Waist Circumference
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to evaluate the relationship between hypertriglyceridemic waist (HW) phenotype,hypertriglyceridemic waist-to-height ratio (HWHtR) phenotype and abnormal glucose metabolism in adolescents. A secondary analysis was conducted on 2626 adolescents aged 12–19 years in United States. Abnormal glucose metabolism was defined as fasting plasma glucose ≥ 5.6 mmol/L or oral glucose tolerance test 2-h plasma glucose ≥ 7.8 mmol/L or glycohemoglobin A1c ≥ 5.7% or a previous diagnosis of diabetes. The HW phenotype was defined as triglyceride(TG) concentrations ≥ 1.47 mmol/L and waist circumference (WC) ≥ 90th percentile. The HWHtR phenotype was defined as TG concentrations ≥ 1.47 mmol/L and waist-to-height ratio (WHtR) ≥ 0.5. 621(23.6%) adolescents had abnormal glucose metabolism. The prevalences of abnormal glucose metabolism were 22.7% and 40.6% in adolescents without and with HW phenotype. The prevalences of abnormal glucose metabolism were 22.4% and 38.6% in adolescents without and with HWHtR phenotype. Adolescents with HWHtR phenotype were more likely to have abnormal glucose metabolism (OR = 1.548, P = 0.010). The levels of homeostasis model assessment insulin resistance and β cell fuction index were higher in adolescents with HWHtR phenotype than in adolescents without HWHtR phenotype (P 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2023.110622