A special polysaccharide hydrogel coated on Brasenia schreberi : preventive effects against ulcerative colitis via modulation of gut microbiota

Ulcerative colitis (UC) is a growing health concern in humans, but it can be prevented by using special dietary strategies. Young stems and leaves of (BS) are coated with a special polysaccharide hydrogel (BS mucilage) which can be beneficial for colon health. The aim of this study was to investigat...

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Bibliographic Details
Published in:Food & function 2023-04, Vol.14 (8), p.3564-3575
Main Authors: Wan, Jiawei, Yu, Xiujuan, Liu, Jiao, Li, Jing, Ai, Tingyang, Yin, Cong, Liu, Hong, Qin, Rui
Format: Article
Language:English
Subjects:
Animals
Bacteria
Brasenia schreberi
Colitis - chemically induced
Colitis, Ulcerative - chemically induced
Colon
Colorectal carcinoma
Dextran Sulfate - adverse effects
Diet
Disease Models, Animal
Gastrointestinal Microbiome
Humans
Hydrogels
Inflammatory bowel disease
Inflammatory bowel diseases
Interleukin 18
Interleukin 6
Intestinal microflora
Mice
Mice, Inbred C57BL
Microbiota
Microorganisms
Modulation
mRNA
Mucilage
Polysaccharides
Polysaccharides - pharmacology
Ulcerative colitis
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Summary:Ulcerative colitis (UC) is a growing health concern in humans, but it can be prevented by using special dietary strategies. Young stems and leaves of (BS) are coated with a special polysaccharide hydrogel (BS mucilage) which can be beneficial for colon health. The aim of this study was to investigate the preventive effects of BS mucilage against UC in a DSS-treated mouse model. Although containing only 0.3% solid content, our research showed that BS mucilage effectively attenuated the disease activity index (DAI) and the spleen index and downregulated IL-1β, IL-18, IL-6 and CAT mRNA levels in DSS-treated mice, which is a promising UC alleviation function. Additionally, BS mucilage also improved the propionate and butyrate levels in mouse feces and alleviated the imbalanced gut microbiota induced by DSS. The abundance of pro-inflammatory and colorectal cancer related bacteria, such as , , and , was decreased by BS mucilage feeding, whereas the abundance of anti-inflammatory and SCFA-producing bacteria including and was increased. In conclusion, the current study shows that the daily consumption of BS mucilage could be an effective way to prevent UC in mice, modulation of gut microbiota.
ISSN:2042-6496
2042-650X
DOI:10.1039/d2fo03207d