An Isothiazolanthrone‐Based Self‐Assembling Anticancer Color‐Changing Dye for Concurrent Imaging and Monitoring of Cell Viability

We report the photophysical properties, self‐assembly and biological evaluation of an isothiazolanthrone‐based dye, 7‐amino‐6H‐anthra[9,1‐cd]isothiazol‐6‐one (AAT), which reveals anticancer properties and can be potentially used as dye for monitoring cell viability. The solvent‐dependent photophysic...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2023-05, Vol.18 (9), p.e202300044-n/a
Main Authors: Gour, Nidhi, Kshtriya, Vivekshinh, Khatun, Sajmina, Bandyopadhyay, Sujoy, Ghosh, Rajib, Koshti, Bharti, Singh, Ramesh, Haque, Ashadul, Bhatia, Dhiraj, Joshi, Khashti Ballabh, Boukhvalov, Danil W., Nath, Sukhendu, Rengan, Aravind K.
Format: Article
Language:English
Subjects:
Animals
Anticancer properties
Biological properties
Cell imaging
Cell Line
Cell Survival
Charge transfer
Chemistry
Computational modeling
Dyes
Emission analysis
Fluorescent dye
Mice
Monitoring
Self-assembly
Solvents
Spectrometry, Fluorescence - methods
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Summary:We report the photophysical properties, self‐assembly and biological evaluation of an isothiazolanthrone‐based dye, 7‐amino‐6H‐anthra[9,1‐cd]isothiazol‐6‐one (AAT), which reveals anticancer properties and can be potentially used as dye for monitoring cell viability. The solvent‐dependent photophysical studies suggest that the emission of AAT is sensitive to environment polarity due to which interesting changes in the colored emission may be observed owing to the charge transfer (CT) processes. AAT also self‐assembles to tree‐like branched morphologies and produce, a greenish emission inside the cells when imaged after short interval (15 mins) of incubation while a red fluorescence could be noted after 24 h. Interestingly, AAT also produce differential emission inside mouse normal cells as compared to its cancer cell lines since it possess anticancer activity. The experimental observations were also validated theoretically via computational modeling. We report the photophysical properties, self‐assembly and biological evaluation of an isothiazolanthrone based dye 7‐Amino‐6H‐anthra[9,1‐cd]isothiazol‐6‐one (AAT) which can be potentially used for concurrent imaging and monitoring of cell viability. Interestingly, AAT reveals anticancer properties due to which it can detect cancer cell differentially as compared to normal cells.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202300044