Cobalt(I)-Catalyzed Reductive Cyclization of Enynes and Diynes Using Hydrogen Gas as a Reductant

Reductive cyclization of enynes and diynes by using H2 gas as a reductant was realized, and the corresponding cyclized products were obtained in good yields without olefin isomerization and over-reduction of the products. By an experiment using D2 instead of H2, it was confirmed that H2 unambiguousl...

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Bibliographic Details
Published in:Organic letters 2023-03, Vol.25 (12), p.2103-2107
Main Authors: Isoda, Kaho, Sato, Yoshihiro
Format: Article
Language:English
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Summary:Reductive cyclization of enynes and diynes by using H2 gas as a reductant was realized, and the corresponding cyclized products were obtained in good yields without olefin isomerization and over-reduction of the products. By an experiment using D2 instead of H2, it was confirmed that H2 unambiguously operates as a reductant in this reaction. The protocol of the reaction is very economical and user-friendly, using air- and moisture-stable CoBr2·6H2O and 1 atm of pressure of H2.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00524