Assessment of the number of mast cells in the soft palate of dogs affected by brachycephalic obstructive airway syndrome

Background Oedema is described in the soft palate of dogs affected by brachycephalic obstructive airway syndrome (BOAS). Activated mast cells (MCs) release vasoactive mediators that temporarily increase vascular permeability. Methods Data and caudal soft palate tissue were prospectively collected fr...

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Bibliographic Details
Published in:Veterinary record 2023-07, Vol.193 (2), p.e2833-e2833
Main Authors: Pérez López, Pablo, Café Marçal, Valéria, Leece, Elizabeth A., Hattersley, Rachel D.
Format: Article
Language:English
Subjects:
Airway Obstruction - surgery
Airway Obstruction - veterinary
Animals
Brachycephalic Obstructive Airway Syndrome
Craniosynostoses - veterinary
Dog Diseases - pathology
Dog Diseases - surgery
Dogs
greyhound
mast cell
Mast Cells - pathology
Mouth
Palate, Soft - pathology
Palate, Soft - surgery
soft palate
Syndrome
Veterinary medicine
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Summary:Background Oedema is described in the soft palate of dogs affected by brachycephalic obstructive airway syndrome (BOAS). Activated mast cells (MCs) release vasoactive mediators that temporarily increase vascular permeability. Methods Data and caudal soft palate tissue were prospectively collected from a population of dogs undergoing surgical management of BOAS and a control group of greyhound cadavers with no previous history of respiratory signs. Histological assessment was performed to quantify the number of MCs within the lamina propria of each group. Results The mean number of MCs in the BOAS group (53 MCs/10 400× high‐power fields [HPF]; standard deviation [SD] = 23) was significantly greater than that in the greyhound group (24 MCs/10 400×HPF; SD = 10). Limitations The small size of the control group and the heterogeneous nature of the dogs in the BOAS group limit the generalisability of the findings. The use of different surgical techniques in the BOAS group may have also affected the degree of inflammation present within the samples. The cohort was not screened for concurrent disease processes that could potentially increase the number of circulating MCs. Conclusion This study demonstrated a statistically significant difference between the numbers of MCs in the soft palate of brachycephalic dogs with clinically significant BOAS and the greyhound control group.
ISSN:0042-4900
2042-7670
DOI:10.1002/vetr.2833