Nitration of Pyrrolo[2,1‑a]isoquinolines

We have successfully modified a series of pyrrolo­[2,1-a]­isoquinolines via direct nitration under mild reaction conditions. Easily accessible nitrates including CAN, Cu­(NO3)2·H2O, and Fe­(NO3)3·9H2O all can serve as effective nitrating reagents for functionalizing pyrrolo­[2,1-a]­isoquinolines. Va...

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Bibliographic Details
Published in:Journal of organic chemistry 2023-04, Vol.88 (7), p.4649-4661
Main Authors: Chen, Xiao-Hui, Ma, Dan-Dan, Gao, Xin, Li, Yun-Meng, Jiang, Da-Bo, Ma, Chao, Cui, Hai-Lei
Format: Article
Language:English
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Summary:We have successfully modified a series of pyrrolo­[2,1-a]­isoquinolines via direct nitration under mild reaction conditions. Easily accessible nitrates including CAN, Cu­(NO3)2·H2O, and Fe­(NO3)3·9H2O all can serve as effective nitrating reagents for functionalizing pyrrolo­[2,1-a]­isoquinolines. Various nitro-bearing pyrrolo­[2,1-a]­isoquinolines have been efficiently prepared in acceptable to good yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c00125