Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study

The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e...

Full description

Saved in:
Bibliographic Details
Published in:Journal of affective disorders 2023-06, Vol.331, p.149-157
Main Authors: Henry, Melissa, Harvey, Raphaële, Chen, Lawrence M., Meaney, Michael, Nguyen, Thi Thu Thao, Kao, Han-Tin, Rosberger, Zeev, Frenkiel, Saul, Hier, Michael, Zeitouni, Anthony, Kost, Karen, Mlynarek, Alex, Richardson, Keith, Greenwood, Celia M.T., Melnychuk, David, Gold, Phil, Chartier, Gabrielle, Black, Martin, Mascarella, Marco, MacDonald, Christina, Sadeghi, Nader, Sultanem, Khalil, Shenouda, Georges, Cury, Fabio, O'Donnell, Kieran John
Format: Article
Language:English
Subjects:
Adult
Anxiety - genetics
Anxiety - psychology
Cancer
Depression
Depression - diagnosis
Depression - genetics
Early detection
Genetic Predisposition to Disease - genetics
Genetics
Head and neck cancer
Head and Neck Neoplasms - genetics
Humans
Inflammation
Inflammation - genetics
Longitudinal Studies
Oncology
Polygenic risk score
Prevention
Prospective Studies
Survival
Symptom burden
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival. Prospective longitudinal study of 223 adults (72 % participation) newly diagnosed with a first occurrence of primary head and neck cancer, paired with genetic data (Illumina PsychArray), validated psychometric measures, Structured Clinical Interviews for DSM Disorders (SCID-I), and medical chart reviews. Symptom burden at 3 months was predicted by (R2 adj. = 0.38, p 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2023.03.007