Cocoa powder and fermented jackfruit seed flour: A comparative cell‐based study on their potential antioxidant and anti‐inflammatory activities after simulated gastrointestinal digestion

BACKGROUND Jackfruit seed flour can be used as a cocoa aroma replacer with similar technological properties. The purpose of this study was to investigate the in vivo toxicity and in vitro antioxidant activity of fermented jackfruit seed flour (Fjs) and non‐alkaline cocoa powder (Nac). RESULTS Fjs an...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2023-08, Vol.103 (10), p.4956-4965
Main Authors: Spada, Fernanda Papa, Lazarini, Josy Goldoni, Batista, Pollyanna Souza, Oliveira Sartori, Alan Giovanini, Saliba, Ana Sofia Martelli Chaib, Pedroso Gomes do Amaral, José Eduardo, Purgatto, Eduardo, Alencar, Severino Matias
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - analysis
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - analysis
Antioxidants - pharmacology
Aroma
Artocarpus - chemistry
Artocarpus heterophyllus
bioavailability
Biocompatibility
Caco‐2 cells
Cell viability
Chocolate
Cocoa
Digestion
Digestive system
Flour
Flour - analysis
Galleria mellonella
Gastrointestinal tract
In vivo methods and tests
Inflammation
Jackfruit
Macrophages
Mice
NF-kappa B - genetics
RAW 264.7 cells
Seeds - chemistry
Toxicity
Tumor Necrosis Factor-alpha - genetics
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Summary:BACKGROUND Jackfruit seed flour can be used as a cocoa aroma replacer with similar technological properties. The purpose of this study was to investigate the in vivo toxicity and in vitro antioxidant activity of fermented jackfruit seed flour (Fjs) and non‐alkaline cocoa powder (Nac). RESULTS Fjs and Nac extracts (Fjs‐E and Nac‐E) were produced and submitted to in vitro gastrointestinal digestion producing digested fractions named Fjs‐D and Nac‐D, respectively. Nac‐E showed over two‐fold higher oxygen radical absorbance capacity (ORAC) than Fjs‐E. However, after simulated gastrointestinal digestion (in vitro), there were no significant differences between Nac‐D and Fjs‐D (P 
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.12568