Role of adipocyte‐derived extracellular vesicles during the progression of liver inflammation to hepatocellular carcinoma

Extracellular vesicles are membrane‐bound cargos that vary in size and are stably transported through various bodily fluids. Extracellular vesicles communicate information between the cells and organs. Extracellular vesicles from the diseased cells alter cellular responses of the recipient cells con...

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Bibliographic Details
Published in:Journal of cellular physiology 2023-06, Vol.238 (6), p.1125-1140
Main Authors: Vp, Venkateish, Kannan, Anbarasu, Perumal, Madan Kumar
Format: Article
Language:English
Subjects:
Adipocytes
biomarker
Biomarkers
Body fluids
Carcinoma, Hepatocellular - pathology
Cirrhosis
Extracellular vesicles
Extracellular Vesicles - pathology
Fibrosis
Hepatocellular carcinoma
Humans
Inflammation
Inflammation - pathology
Liver
Liver cancer
Liver cirrhosis
Liver diseases
liver fibrosis
Liver Neoplasms - pathology
Membrane vesicles
Vesicles
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Summary:Extracellular vesicles are membrane‐bound cargos that vary in size and are stably transported through various bodily fluids. Extracellular vesicles communicate information between the cells and organs. Extracellular vesicles from the diseased cells alter cellular responses of the recipient cells contributing to disease progression. In obesity, adipocytes become hypertrophic and the extracellular vesicles from these dysfunctional adipocytes showed altered cargo contents instigating pathophysiological response leading to chronic liver diseases. In this review, the role of adipocyte‐derived extracellular vesicles on the progression of liver inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma are extensively discussed. Newer approaches are crucial to take advantage of extracellular vesicles and their content as biomarkers to diagnose initial liver inflammation before reaching to an irreversible liver failure stage.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.31008