Modeling unrelated blood stem cell donor recruitment using simulated registrant cohorts: Assessment of human leukocyte antigen matching across ethnicity groups

Background Human leukocyte antigen (HLA)‐matched unrelated donors are not available for some patients considered for allogeneic hematopoietic cell transplantation, particularly among certain ethnic groups. Simulated recruitment modeling can inform efforts to find new matches for more patients. Metho...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2023-05, Vol.63 (5), p.1060-1066
Main Authors: Blake, John T., Parmar, Gaganvir, Ganz, Kathy, Seftel, Matthew D., Allan, David S.
Format: Article
Language:English
Subjects:
allogeneic
Allografts
Antigens
Blood
Canada
Data search
Ethnicity
Haplotypes
hematopoietic cell transplant
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Histocompatibility antigen HLA
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Histocompatibility Testing
HLA Antigens - genetics
HLA‐matching
Humans
Leukocytes
Matching
Minority & ethnic groups
Modelling
Recruitment
Registries
simulated recruitment
Simulation
stem cell registry
Stem cell transplantation
Stem Cells
Transplantation
Unrelated Donors
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Summary:Background Human leukocyte antigen (HLA)‐matched unrelated donors are not available for some patients considered for allogeneic hematopoietic cell transplantation, particularly among certain ethnic groups. Simulated recruitment modeling can inform efforts to find new matches for more patients. Methods Simulated recruits were generated by assigning a pair of donor HLA haplotypes from historical data files and matched against HLA data of patient searches in the Canadian Blood Services Stem Cell Registry. Recruitment cohorts reflected the proportion of five specific ethnic groups in the 2016 Canadian census data. Results Novel 8/8 HLA matches between simulated recruits and patients increased linearly with larger recruitment cohorts. The proportion of novel 8/8 HLA matches from Caucasian, Hispanic, and Native American/First Nations recruits was equal to or greater than their relative proportion in the recruited cohort (match to: recruit ratio (MRR) ≥ 1). In contrast, African American and Asian & Pacific Islander recruits represented a smaller proportion of novel matches relative to their percentage of the recruited cohort (MRR 
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17310