Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi

is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse series of furanones for their potential to inhibit quorum sensing. A library of ha...

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Bibliographic Details
Published in:Future medicinal chemistry 2023-02, Vol.15 (4), p.317-332
Main Authors: Pinheiro, Jorge, Lyons, Thérèse, Heras, Vanessa Las, Recio, Miguel Villoria, Gahan, Cormac Gm, O'Sullivan, Timothy P
Format: Article
Language:English
Subjects:
Quorum Sensing
Vibrio
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Summary:is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse series of furanones for their potential to inhibit quorum sensing. A library of halogenated furanones was prepared and derivatized using standard Pd-mediated coupling reactions and subsequently evaluated for their effects on bioluminescence. Several furanones inhibited QS-regulated bioluminescence, with -dichlorofuranone and tribromofuranone compounds proving especially effective. Importantly, a number of compounds were effective inhibitors of bioluminescence but did not have an impact on bacterial growth.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2022-0235