Association between hypogammaglobulinaemia and severe infections during induction therapy in ANCA-associated vasculitis: from J-CANVAS study

To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the development of severe infections. We conducted a retrospective cohort study of patients with new-onset...

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Published in:Rheumatology (Oxford, England) England), 2023-12, Vol.62 (12), p.3924-3931
Main Authors: Omura, Satoshi, Kida, Takashi, Noma, Hisashi, Sunaga, Atsuhiko, Kusuoka, Hiroaki, Kadoya, Masatoshi, Nakagomi, Daiki, Abe, Yoshiyuki, Takizawa, Naoho, Nomura, Atsushi, Kukida, Yuji, Kondo, Naoya, Yamano, Yasuhiko, Yanagida, Takuya, Endo, Koji, Hirata, Shintaro, Matsui, Kiyoshi, Takeuchi, Tohru, Ichinose, Kunihiro, Kato, Masaru, Yanai, Ryo, Matsuo, Yusuke, Shimojima, Yasuhiro, Nishioka, Ryo, Okazaki, Ryota, Takata, Tomoaki, Ito, Takafumi, Moriyama, Mayuko, Takatani, Ayuko, Miyawaki, Yoshia, Ito-Ihara, Toshiko, Yajima, Nobuyuki, Kawaguchi, Takashi, Fukuda, Wataru, Kawahito, Yutaka
Format: Article
Language:English
Subjects:
Agammaglobulinemia - chemically induced
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy
Antibodies, Antineutrophil Cytoplasmic
Churg-Strauss Syndrome
Granulomatosis with Polyangiitis - drug therapy
Humans
Immunoglobulin G - therapeutic use
Induction Chemotherapy
Microscopic Polyangiitis - drug therapy
Retrospective Studies
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Summary:To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the development of severe infections. We conducted a retrospective cohort study of patients with new-onset or severe relapsing AAV enrolled in the J-CANVAS registry, which was established at 24 referral sites in Japan. The minimum serum IgG levels up to 24 weeks and the incidence of severe infection up to 48 weeks after treatment initiation were evaluated. After multiple imputations for all explanatory variables, we performed the multivariate analysis using a Fine-Gray model to assess the association between low IgG (the minimum IgG levels
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kead138