Basic research on curcumin in cervical cancer: Progress and perspectives

Curcumin is a polyphenolic substance extracted from plants such as Curcuma longa, Curcuma zedoaria, and radix curcumae, and it has attracted much attention because of the anti-inflammatory, antioxidant, anti-tumor, antibacterial and other multiple pharmacological effects. Cervical cancer is one of t...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2023-06, Vol.162, p.114590-114590, Article 114590
Main Authors: Zhang, Xiaoyu, Zhu, Lin, Wang, Xuezhen, Zhang, Hairong, Wang, Lianzhong, Xia, Lei
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Cervical cancer
Curcumin
Curcumin - pharmacology
Female
Humans
Mechanism
Papillomavirus Infections
Pathway
Plants
Systematic Reviews as Topic
Uterine Cervical Neoplasms
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Summary:Curcumin is a polyphenolic substance extracted from plants such as Curcuma longa, Curcuma zedoaria, and radix curcumae, and it has attracted much attention because of the anti-inflammatory, antioxidant, anti-tumor, antibacterial and other multiple pharmacological effects. Cervical cancer is one of the most common malignant tumors in women. With the application of HPV (human papillomavirus) vaccine, the incidence of cervical cancer is expected to be reduced, but it remains difficult to promote the vaccine among low-income population. As a commonly used food additive, curcumin has recently been found to have a significant therapeutic effect in the treatment of cervical cancer. In recent years, numerous in vitro and in vivo studies have found that curcumin can have significant efficacy in anti-cervical cancer treatment by promoting apoptosis, inhibiting tumour cell proliferation, metastasis and invasion, inhibiting HPV and inducing autophagy in tumour cells. However, due to poor water solubility, rapid catabolism, and low bioavailability of curcumin, studies on curcumin derivatives and novel formulations are increasing. Curcumin has a wide range of mechanisms of action against cervical cancer and may become a novel antitumor drug in the future, opening up new ideas for the research of curcumin in the field of antitumor. There is a lack of systematic reviews on the mechanism of action of curcumin against cervical cancer. Therefore, this study is a review of the literature based on the mechanism of action of curcumin against cervical cancer, with a view to providing reference information for scientific and clinical practitioners.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.114590