Insulin resistance is more frequent in type 1 diabetes patients with long disease duration

Aims To investigate the clinical status of insulin resistance (IR) and its correlation with disease duration in patients with type 1 diabetes (T1D). Materials and Methods Cross‐sectional data from a T1D cohort were obtained (n = 923). IR‐related metabolic disorders including hypertension, obesity, a...

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Published in:Diabetes/metabolism research and reviews 2023-09, Vol.39 (6), p.e3640-n/a
Main Authors: Xie, Yuting, Shi, Mei, Ji, Xiaolin, Huang, Fansu, Fan, Li, Li, Xia, Zhou, Zhiguang
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Diabetes
Diabetes mellitus (insulin dependent)
Disease
Dyslipidemia
estimated glucose disposal rate
Insulin resistance
Metabolic disorders
Metabolic syndrome
Multivariate analysis
Regression analysis
type 1 diabetes
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Summary:Aims To investigate the clinical status of insulin resistance (IR) and its correlation with disease duration in patients with type 1 diabetes (T1D). Materials and Methods Cross‐sectional data from a T1D cohort were obtained (n = 923). IR‐related metabolic disorders including hypertension, obesity, and dyslipidemia were used as outcome variables to explore the cut‐off point for estimated glucose disposal rate (eGDR) by restricted cubic spline (RCS) curve. Regression models were used for multivariate analysis of the clinical factors associated with IR. The correlation between the status of IR and diabetes duration was depicted with the RCS curve. Results IR‐related metabolic disorders were observed in 39.4% of patients, with 9.1% meeting the criteria for metabolic syndrome. Specifically, patients with ≥10 years of T1D were more likely to have IR‐related metabolic disorders (54.7% vs. 36.9%, p 
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3640