Expanding Liver Transplant Opportunities in Older Patients With Nonconventional Grafts

Broader use of donation after circulatory death (DCD) and nonconventional grafts for liver transplant helps reduce disparities in organ availability. Limited data, however, exists on outcomes specific to nonconventional graft utilization in older patients. As such, this study aimed to investigate ou...

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Bibliographic Details
Published in:The Journal of surgical research 2023-08, Vol.288, p.140-147
Main Authors: Egbert, Lena K., Ohara, Stephanie Y., Das, Devika, Brooks, Abigail, Mahdi, Giyth, Aqel, Bashar, Buckner Petty, Skye A., Mathur, Amit K., Moss, Adyr, Reddy, Kunam S., Jadlowiec, Caroline C.
Format: Article
Language:English
Subjects:
Age
Aged
Death
Deceased donor
Donor pool
End Stage Liver Disease - surgery
Graft Survival
Graft type
Humans
Liver Transplantation
Marginal donor
Organ shortage
Retrospective Studies
Severity of Illness Index
Tissue and Organ Procurement
Tissue Donors
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Summary:Broader use of donation after circulatory death (DCD) and nonconventional grafts for liver transplant helps reduce disparities in organ availability. Limited data, however, exists on outcomes specific to nonconventional graft utilization in older patients. As such, this study aimed to investigate outcomes specific to conventional and nonconventional graft utilization in recipients > 70 y of age. 1-to-3 matching based on recipient sex, Model for End-Stage Liver Disease score, and donor type was performed on patients ≥70 and 70 y, there were no differences in patient (P = 0.89) or graft (P = 0.71) survival. Excellent outcomes can be achieved in older recipients, even with use of nonconventional grafts. Expanded use of nonconventional grafts can help facilitate transplant opportunities in older patients.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2023.01.017