Chemical constituents from the aerial parts of Rubia cordifolia L. with their NO inhibitory activity

A new naphthoquinone derivative (1) together with twenty-three known compounds (2-24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1-13 were assessed for their inhibitory effects on NO production in LPS-...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2024-02, Vol.38 (5), p.711-718
Main Authors: Zhang, Hong, Fang, Wen-Tao, Li, Yan, Kong, Qing-Hua, Fang, Cheng-Wu, Luo, Han, Liu, Shou-Jin
Format: Article
Language:English
Subjects:
flavonoids
Macrophages
naphthoquinone derivative
NMR
NO inhibitory activity
Nuclear magnetic resonance
Rubia cordifolia
Rubia cordifolia L
Rubiaceae
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new naphthoquinone derivative (1) together with twenty-three known compounds (2-24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1-13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC 50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L −1 , respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2192491