Gestational low dietary protein induces intrauterine inflammation and alters the programming of adiposity and insulin sensitivity in the adult offspring

Malnutrition associated with low dietary protein can induce gestational inflammation and sets a long-lasting metabolic impact on the offspring even after replenishment. The work investigated whether a low-protein diet (LPD) during pregnancy and lactation induces intrauterine inflammation and predisp...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of nutritional biochemistry 2023-06, Vol.116, p.109330-109330, Article 109330
Main Authors: Mohammed, Shujauddin, Qadri, Syed Shah Yousuf Hussain, Molangiri, Archana, Basak, Sanjay, Rajkumar, Hemalatha
Format: Article
Language:English
Subjects:
Adiposity
Adiposity - physiology
Body Weight
Diet, Protein-Restricted - adverse effects
Dietary Proteins
Fasting glucose
Female
Humans
Inflammation - metabolism
Insulin Resistance
Intrauterine inflammation
Lactation
Low-protein diet
Maternal Nutritional Physiological Phenomena - physiology
Obesity - etiology
Obesity - metabolism
Placenta - metabolism
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Pro-inflammatory cytokines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malnutrition associated with low dietary protein can induce gestational inflammation and sets a long-lasting metabolic impact on the offspring even after replenishment. The work investigated whether a low-protein diet (LPD) during pregnancy and lactation induces intrauterine inflammation and predisposes offspring to adiposity and insulin resistance in their adult life. Female Golden Syrian hamsters were fed LPD (10.0% energy from protein) or a control diet (CD, 20.0 % energy from protein) from preconception until lactation. All pups were switched to CD after lactation and continued until the end. Maternal LPD increased intrauterine inflammation by enhancing neutrophil infiltration, amniotic hsCRP, oxidative stress, and mRNA expression of NFκβ, IL8, COX2, and TGFβ in the chorioamniotic membrane (P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2023.109330